| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| I129856-100mg | 100mg | 3 | $9.90 | |
| I129856-500mg | 500mg | 3 | $29.90 | |
| I129856-1g | 1g | 2 | $53.90 | |
| I129856-5g | 5g | 3 | $189.90 | |
| I129856-25g | 25g | 3 | $659.90 | |
| I129856-100g | 100g | 2 | $1,799.90 |
| Synonyms | 13 Cis-Retinoic Acid | HSDB 3929 | ISOTRETINOIN [MI] | BSPBio_000072 | Isosuprea Lidose | Roacutan | isotretinoina | Ro-43780 | Ro-4-3780 | 2-cis-vitamin A acid | ISOTRETINOIN (USP MONOGRAPH) | ISOTRETINOIN [EP MONOGRAPH] | Isotretinoine [INN-French] | PA |
|---|---|
| Specifications & Purity | Moligand™, ≥98% |
| Biochemical and Physiological Mechanisms | 13-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation and induces cell differentiation. 13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action. The action of RA is mediated through RAR-β and RAR-α receptors. RA attenua |
| Storage Temp | Store at -20°C,Argon charged |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Action Type | AGONIST |
| Mechanism of action | Retinoic acid receptor agonist |
| Product Description | A vitamin A analog that inhibits cell proliferation. 13-cis-Retinoic acid has been used: · as a component of fresh media for LA-N-5 differentiation · to treat medulloblastoma cells for cell differentiation · to treat spheroids for generating time-lapse videos · to examine its head- deforming activity under light and dark conditions in Xenopus laevis |
| ALogP | 6.3 |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Pubchem Sid | 504763423 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504763423 |
| IUPAC Name | (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid |
| INCHI | InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- |
| InChi Key | SHGAZHPCJJPHSC-XFYACQKRSA-N |
| Canonical SMILES | CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C |
| Isomeric SMILES | CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C\C(=O)O)/C)/C |
| WGK Germany | 3 |
| RTECS | VH6440000 |
| PubChem CID | 5282379 |
| Molecular Weight | 300.44 |
| Beilstein | 9(4)2388 |
| Reaxy-Rn | 1885770 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 I2406510 | Certificate of Analysis | Aug 26, 2024 | I129856 |
| I2419478 | Certificate of Analysis | Aug 26, 2024 | I129856 |
| I2419479 | Certificate of Analysis | Aug 26, 2024 | I129856 |
| K2212467 | Certificate of Analysis | Aug 23, 2024 | I129856 |
| K2212470 | Certificate of Analysis | Aug 23, 2024 | I129856 |
| K2212498 | Certificate of Analysis | Aug 23, 2024 | I129856 |
| K2212499 | Certificate of Analysis | Aug 23, 2024 | I129856 |
| K2212500 | Certificate of Analysis | Aug 23, 2024 | I129856 |
| K2212478 | Certificate of Analysis | Aug 14, 2024 | I129856 |
| H2124307 | Certificate of Analysis | Jun 07, 2023 | I129856 |
| H2124309 | Certificate of Analysis | Jun 07, 2023 | I129856 |
| H2124326 | Certificate of Analysis | Jun 07, 2023 | I129856 |
| K2011171 | Certificate of Analysis | Sep 17, 2022 | I129856 |
| Pictogram(s) | GHS08, GHS09, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H360:May damage fertility or the unborn child |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| RTECS | VH6440000 |
| Reaxy-Rn | 1885770 |
| Merck Index | 5228 |
Starting at $125.90
| 1. Peng Zhang, Lei Tian, Jiayu Bao, Shang Li, Ao Li, Ya Wen, Jingyi Wang, Ying Jie. (2022) Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 63 (3): (29-29). [PMID:35353124] [10.1167/iovs.63.3.29] |
| 1. Layton A. (2009) The use of isotretinoin in acne.. Dermatoendocrinol, 1 (3): (162-9). [PMID:20436884] [10.1021/op500134e] |
| 2. Sonawane P, Cho HE, Tagde A, Verlekar D, Yu AL, Reynolds CP, Kang MH. (2014) Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma.. Br J Pharmacol, 171 (23): (5330-44). [PMID:25039756] [10.1021/op500134e] |
| 3. Peng Zhang, Lei Tian, Jiayu Bao, Shang Li, Ao Li, Ya Wen, Jingyi Wang, Ying Jie. (2022) Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 63 (3): (29-29). [PMID:35353124] [10.1167/iovs.63.3.29] |
