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INCB3619 , CAS No.I611056, Inhibitor of ADAM33;Inhibitor of ADAM8

Item Number

I611056

Grouped product items
SKU	Size	Availability	Price	Qty
I611056-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
I611056-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	INCB3619 \| INCB-3619 \| 791826-72-7 \| UNII-Q56UE7E40Y \| Q56UE7E40Y \| INCB 3619 \| CHEMBL434567 \| methyl (5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenyl3,6-dihydro-2H-pyridine-1-carbonyl)-7-azaspiro[2.5]octane-7-carboxylate \| IAI-100 \| 5-Azaspiro(2.5)octane-5-carboxylic acid, 6
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of ADAM33;Inhibitor of ADAM8

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	methyl (5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenyl3,6-dihydro-2H-pyridine-1-carbonyl)-7-azaspiro[2.5]octane-7-carboxylate
INCHI	InChI=1S/C22H27N3O5/c1-30-21(28)25-14-22(9-10-22)13-17(19(26)23-29)18(25)20(27)24-11-7-16(8-12-24)15-5-3-2-4-6-15/h2-7,17-18,29H,8-14H2,1H3,(H,23,26)/t17-,18-/m0/s1
InChi Key	CKZHFOKQZRZCPF-ROUUACIJSA-N
Canonical SMILES	ONC(=O)[C@H]1CC2(CC2)CN([C@@H]1C(=O)N1CCC(=CC1)c1ccccc1)C(=O)OC
Isomeric SMILES	COC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N3CCC(=CC3)C4=CC=CC=C4)C(=O)NO
PubChem CID	11625778

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

1. Georgiadis D, Yiotakis A. (2008) Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.. Bioorg Med Chem, 16 (19): (8781-94). [PMID:18790648] [10.1021/op500134e]

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