| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| V100750-250mg | 250mg | 2 | $85.90 | |
| V100750-1g | 1g | 3 | $254.90 |
| Synonyms | Hydroxocobalamin hydrochloride | Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with (5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole-kappaN3), hydrochloride | cobalt(3+);[5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydro |
|---|---|
| Specifications & Purity | ≥90% |
| Biochemical and Physiological Mechanisms | Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. The physiologically active forms of vitamin B12 include m |
| Storage Temp | Store at 2-8°C,Argon charged |
| Shipped In | Wet ice |
| Product Description | application： Vitamin B12a hydrochloride has been used as an antidote for cyanide poisoning. |
| Pubchem Sid | 504763887 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504763887 |
| IUPAC Name | cobalt(3+);[5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[(5Z,10Z,14Z)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-1,2,7,12,17,23-hexahydrocorrin-3-yl]propanoylamino]propan-2-yl phosphate;hydroxide;hydrochloride |
| INCHI | InChI=1S/C62H90N13O14P.ClH.Co.H2O/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;;/h20-21,23,28,31,34-37,41,52-53,56-57,71,76,84H,12-19,22,24-27H2,1-11H3,(H2,63,77)(H2,64,78)(H2,65,79)(H2,66,80)(H2,67,81)(H2,68,82)(H,69,83)(H,85,86);1H;;1H2/q;;+3;/p-2/b38-23-,50-32-,55-33-;;; |
| InChi Key | CGILFMTUCMTNCZ-MAQCMGFJSA-L |
| Canonical SMILES | CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=N6)C(=C7C(C(C(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)N7)CCC(=O)N)(C)CC(=O)N)C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[OH-].Cl.[Co+3] |
| Isomeric SMILES | CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=N6)/C(=C\7/C(C(/C(=C/C8=N/C(=C(\C4=N5)/C)/C(C8(C)C)CCC(=O)N)/N7)CCC(=O)N)(C)CC(=O)N)/C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[OH-].Cl.[Co+3] |
| WGK Germany | 3 |
| Alternate CAS | 58288-50-9 |
| PubChem CID | 5488668 |
| Molecular Weight | 1346.32（free base） |
| WGK Germany | 3 |
|---|
| 1. Mamoru Yamanishi,Monica Vlasie,Ruma Banerjee. (2005-06-14) Adenosyltransferase: an enzyme and an escort for coenzyme B12?. Trends in biochemical sciences, 30 ((6)): (304-308). [PMID:15950874] |
| 2. Ruma Banerjee. (2006-12-14) B12 trafficking in mammals: A for coenzyme escort service.. ACS chemical biology, 1 ((3)): (149-159). [PMID:17163662] |
| 3. Luciana Hannibal,Jihoe Kim,Nicola E Brasch,Sihe Wang,David S Rosenblatt,Ruma Banerjee,Donald W Jacobsen. (2009-05-19) Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product.. Molecular genetics and metabolism, 97 ((4)): (260-266). [PMID:19447654] |
| 4. Jihoe Kim,Luciana Hannibal,Carmen Gherasim,Donald W Jacobsen,Ruma Banerjee. (2009-10-06) A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins.. The Journal of biological chemistry, 284 ((48)): (33418-33424). [PMID:19801555] |
| 5. Karl Gruber,Barbara Puffer,Bernhard Kräutler. (2011-06-21) Vitamin B12-derivatives-enzyme cofactors and ligands of proteins and nucleic acids.. Chemical Society reviews, 40 ((8)): (4346-4363). [PMID:21687905] |
| 6. Markos Koutmos,Carmen Gherasim,Janet L Smith,Ruma Banerjee. (2011-06-24) Structural basis of multifunctionality in a vitamin B12-processing enzyme.. The Journal of biological chemistry, 286 ((34)): (29780-29787). [PMID:21697092] |
| 7. Hitesh V Motwani,Margareta Törnqvist. (2014-12-03) In vivo doses of butadiene epoxides as estimated from in vitro enzyme kinetics by using cob(I)alamin and measured hemoglobin adducts: an inter-species extrapolation approach.. Toxicology and applied pharmacology, 281 ((3)): (276-284). [PMID:25448046] |
| 8. C M Miller,S Ganesh,C B Garland,D M Leathwick. (2015-01-16) Production benefits from pre- and post-lambing anthelmintic treatment of ewes on commercial farms in the southern North Island of New Zealand.. New Zealand veterinary journal, 63 ((4)): (211-219). [PMID:25589215] |
| 9. Jasmin Federizon,Conrard Giresse Tetsassi Feugmo,Wei-Chiao Huang,Xuedan He,Kazutoyo Miura,Aida Razi,Joaquin Ortega,Mikko Karttunen,Jonathan F Lovell. (2021-01-21) Experimental and Computational Observations of Immunogenic Cobalt Porphyrin Lipid Bilayers: Nanodomain-Enhanced Antigen Association.. Pharmaceutics, 13 ((1)): [PMID:33466686] |
| 10. R Pace,M Bon Homme,R S Hoffman,D Lugassy. (2014-08-05) Effects of hydroxocobalamin on carboxyhemoglobin measured under physiologic and pathologic conditions.. Clinical toxicology (Philadelphia, Pa.), 52 ((7)): (647-650). [PMID:25089720] |
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