| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| H287038-5mg | 5mg | 1 | $47.90 | |
| H287038-10mg | 10mg | 1 | $106.90 | |
| H287038-25mg | 25mg | 1 | $238.90 | |
| H287038-50mg | 50mg | 1 | $430.90 | |
| H287038-100mg | 100mg | 1 | $774.90 |
ATP-competitive inhibitor of DAPK and ZIPK
| Synonyms | Z247384094 | 2-[[1-(3-chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl]propanamide | 1030203-81-6 | AKOS040748537 | BDBM104065 | NCGC00487352-01 | CS-0009364 | 2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]pro |
|---|---|
| Specifications & Purity | ≥98%(HPLC) |
| Biochemical and Physiological Mechanisms | ATP-competitive inhibitor of DAPK (IC50= 200 nM) and ZIPK (Kd= 280 nM). Also inhibits PIM3 kinase (IC50= 200 nM) but exhibits no significant effect on Src or Abl kinases. Reduces phosphorylation of regulatory myosin light chain and myosin light chain phos |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Pubchem Sid | 504773223 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773223 |
| IUPAC Name | 2-[[1-(3-chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl]propanamide |
| INCHI | InChI=1S/C14H12ClN5O2S/c1-7(11(16)21)23-14-18-12-10(13(22)19-14)6-17-20(12)9-4-2-3-8(15)5-9/h2-7H,1H3,(H2,16,21)(H,18,19,22) |
| InChi Key | NASYEGAVCTZSDO-UHFFFAOYSA-N |
| Canonical SMILES | CC(C(=O)N)SC1=NC2=C(C=NN2C3=CC(=CC=C3)Cl)C(=O)N1 |
| Isomeric SMILES | CC(C(=O)N)SC1=NC2=C(C=NN2C3=CC(=CC=C3)Cl)C(=O)N1 |
| WGK Germany | 3 |
| PubChem CID | 135398509 |
| Molecular Weight | 349.8 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 K2301263 | Certificate of Analysis | Oct 19, 2023 | H287038 |
| K2301264 | Certificate of Analysis | Oct 19, 2023 | H287038 |
| K2301265 | Certificate of Analysis | Oct 19, 2023 | H287038 |
| K2301266 | Certificate of Analysis | Oct 19, 2023 | H287038 |
| K2301267 | Certificate of Analysis | Oct 19, 2023 | H287038 |
| K2301268 | Certificate of Analysis | Oct 19, 2023 | H287038 |
| K2301269 | Certificate of Analysis | Oct 19, 2023 | H287038 |
| K2301278 | Certificate of Analysis | Oct 19, 2023 | H287038 |
| K2301286 | Certificate of Analysis | Oct 19, 2023 | H287038 |
| K2301335 | Certificate of Analysis | Oct 19, 2023 | H287038 |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| RIDADR | NONHforallmodesoftransport |
