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Hesperidin - 97%, high purity , CAS No.520-26-3

23 Citations

≥97%

CAS#: 520-26-3
Molecular Weight: 610.56
Beilstein Registry Number: 75140
EC Number: 208-288-1
MDL number: MFCD00075663
PubChem CID: 10621

Item Number

H105437

Grouped product items
SKU	Size	Availability	Price
H105437-5g	5g	5	$13.90
H105437-10g	10g	5	$21.90
H105437-25g	25g	3	$41.90
H105437-100g	100g	1	$120.90
H105437-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$542.90

Flavonoid

View related series

Apoptosis (0) Endogenous Metabolite (0) Immunology/Inflammation (0) Metabolic Enzyme/Protease (0) NF-κB (0) Reactive Oxygen Species (0)

Basic Description

Synonyms	(2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside \| CHEBI:28775 \| DIOSVEIN \| EINECS 208-288-1 \| Hesperetin 7 Rhamnoglucoside \| Q385937 \| D01038 \| hesperidin \| DTXSID9
Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	Flavonoid phytochemical extracted from citrus species. It is the rhamnoglucoside of hesperetin.Flavonoid. Shows anti-oxidant, antibacterial and anti-inflammatory activites. A potent chemopreventive agent.
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

AI Insight

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one
INCHI	InChI=1S/C28H34O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-7,10,17,19,21-30,32-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1
InChi Key	QUQPHWDTPGMPEX-QJBIFVCTSA-N
Canonical SMILES	COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2
Isomeric SMILES	C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=O)C[C@H](OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O
WGK Germany	3
Molecular Weight	610.56
Beilstein	75140

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

14 results found

Lot Number	Certificate Type	Date	Item
G23261477	Certificate of Analysis	Aug 01, 2023	H105437
G23261483	Certificate of Analysis	Aug 01, 2023	H105437
G2326635	Certificate of Analysis	Aug 01, 2023	H105437
G2326637	Certificate of Analysis	Aug 01, 2023	H105437
G2326639	Certificate of Analysis	Aug 01, 2023	H105437
G2326653	Certificate of Analysis	Aug 01, 2023	H105437
G2326658	Certificate of Analysis	Aug 01, 2023	H105437
G2326770	Certificate of Analysis	Aug 01, 2023	H105437
G2326778	Certificate of Analysis	Aug 01, 2023	H105437
F2320032	Certificate of Analysis	Jul 04, 2023	H105437
C2218271	Certificate of Analysis	Mar 23, 2022	H105437
C2218287	Certificate of Analysis	Mar 23, 2022	H105437
C2218302	Certificate of Analysis	Mar 23, 2022	H105437
C2218305	Certificate of Analysis	Mar 23, 2022	H105437

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Safety and Hazards(GHS)

WGK Germany	3
Merck Index	4671

Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Min-Rui Tai, Hong-Wu Ji, Jian-Ping Chen, Xiao-Fei Liu, Bing-Bing Song, Sai-Yi Zhong, Aaqil Rifai, David R. Nisbet, Colin J. Barrow, Richard J. Williams, Rui Li. (2023) Biomimetic triumvirate nanogel complexes via peptide-polysaccharide-polyphenol self-assembly. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 251 (126232). [PMID:37562478] [10.1016/j.ijbiomac.2023.126232]
2. Hong-Qi Xia, Wanbing Chen, Diyang Qiu, Jiwu Zeng. (2023) Portable Microelectrochemical Sensors for Rapid and Sensitive Determination of Hesperidin in Citrus reticulate ‘Chachi’ Peel. MOLECULES, 28 (14): (5316). [PMID:37513189] [10.3390/molecules28145316]
3. Xiao-Hua Zhang, Xiang-Dong Qing, Jing-Jing Zheng, Yan Yu, Jiaojiao Huang, Chao Kang, Zhi Liu. (2023) Aqueous two-phase systems coupled with chemometrics-enhanced HPLC-DAD for simultaneous extraction and determination of flavonoids in honey. Food Chemistry-X, 19 (100766). [PMID:37780266] [10.1016/j.fochx.2023.100766]
4. Shengxiang Yi, Gaowei Zhang, Mingyan Liu, Wenjie Yu, Guohua Cheng, Liping Luo, Fangjian Ning. (2023) Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice. Nutrients, 15 (5): (1078). [PMID:36904078] [10.3390/nu15051078]
5. Pan Lixia, Ye Hangyu, Pi Xionge, Liu Wei, Wang Zhao, Zhang Yinjun, Zheng Jianyong. (2023) Effects of several flavonoids on human gut microbiota and its metabolism by in vitro simulated fermentation. Frontiers in Microbiology, 14 [PMID:36819019] [10.3389/fmicb.2023.1092729]
6. Hong-qi Xia, Diyang Qiu, Wanbing Chen, Genlin Mao, Jiwu Zeng. (2023) In situ formed and fully integrated laser-induced graphene electrochemical chips for rapid and simultaneous determination of bioflavonoids in citrus fruits. MICROCHEMICAL JOURNAL, 188 (108474). [PMID:] [10.1016/j.microc.2023.108474]
7. Chun Xiao Li, Fu Rong Wang, Bing Zhang, Ze Yuan Deng, Hong Yan Li. (2023) Stability and antioxidant activity of phenolic compounds during in vitro digestion. JOURNAL OF FOOD SCIENCE, 88 (2): (696-716). [PMID:36617678] [10.1111/1750-3841.16440]
8. Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo. (2023) Chemical composition and anti-inflammatory activities of Castanopsis honey. Food & Function, 14 (1): (250-261). [PMID:36484340] [10.1039/D2FO02233H]
9. Yu Bo, Luo Shiyu, Ding Yuhan, Gong Zijie, Nie Ting. (2022) Insights into glycosidic bond specificity of an engineered selective α-L-rhamnosidase N12-Rha via activity assays and molecular modelling. AMB Express, 12 (1): (1-14). [PMID:36370155] [10.1186/s13568-022-01489-5]
10. Dan Yu, Fei Liu, Changdong Zou, Xiao Yang. (2023) Municipal green waste promotes iron release from steelmaking slag in water. RESOURCES CONSERVATION AND RECYCLING, 188 (106722). [PMID:] [10.1016/j.resconrec.2022.106722]
11. Qi Quan, Wei Liu, Jiajing Guo, Meiling Ye, Juhua Zhang. (2022) Effect of Six Lactic Acid Bacteria Strains on Physicochemical Characteristics, Antioxidant Activities and Sensory Properties of Fermented Orange Juices. Foods, 11 (13): (1920). [PMID:35804736] [10.3390/foods11131920]
12. Ye Hangyu, Li Xiaojun, Li Luyuan, Zhang Yinjun, Zheng Jianyong. (2022) Homologous Expression and Characterization of α-L-rhamnosidase from Aspergillus niger for the Transformation of Flavonoids. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 194 (8): (3453-3467). [PMID:35366188] [10.1007/s12010-022-03894-9]
13. Hong-qi Xia, Tingting Gu, Ruiyi Fan, Jiwu Zeng. (2022) Comparative investigation of bioflavonoid electrocatalysis in 1D, 2D, and 3D carbon nanomaterials for simultaneous detection of naringin and hesperidin in fruits. RSC Advances, 12 (11): (6409-6415). [PMID:35424592] [10.1039/D1RA07217J]
14. Xiangrong Li, Ruonan Xu, Zeqing Cheng, Zhizhi Song, Ziyang Wang, Hanxiao Duan, Xinzhe Wu, Tianjun Ni. (2021) Comparative study on the interaction between flavonoids with different core structures and hyaluronidase. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 262 (120079). [PMID:34175762] [10.1016/j.saa.2021.120079]
15. Dan-Hua He, Yu-Fei Chen, Yi-Le Zhou, Shi-Bing Zhang, Ming Hong, Xianjun Yu, Su-Fen Wei, Xiang-Zhen Fan, Si-Yi Li, Qi Wang, Yongzhi Lu, Yong-Qiang Liu. (2021) Phytochemical library screening reveals betulinic acid as a novel Skp2-SCF E3 ligase inhibitor in non–small cell lung cancer. CANCER SCIENCE, 112 (8): (3218-3232). [PMID:34080260] [10.1111/cas.15005]
16. Lingrong Wen, Mingyang He, Chunxiao Yin, Yueming Jiang, Donghui Luo, Bao Yang. (2021) Phenolics in Citrus aurantium fruit identified by UHPLC-MS/MS and their bioactivities. LWT-FOOD SCIENCE AND TECHNOLOGY, 147 (111671). [PMID:] [10.1016/j.lwt.2021.111671]
17. Zhang Xiao-Hua, Ma Yi-Xin, Yi Chong, Qing Xiang-Dong, Liu Zhi, Zheng Jing-Jing, Lin Fang, Lv Tian-Feng. (2020) Chemometrics-enhanced HPLC–DAD as a rapid and interference-free strategy for simultaneous quantitative analysis of flavonoids in Chinese propolis. EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 246 (10): (1909-1918). [PMID:] [10.1007/s00217-020-03543-7]
18. Hui Guo, Yunfei Chen, Na Song, Xinyi Yang, Shen Yao, Junqing Qian. (2020) Screening of lipase inhibitors from bamboo leaves based on the magnetic ligand fishing combined with HPLC/MS. MICROCHEMICAL JOURNAL, 153 (104497). [PMID:] [10.1016/j.microc.2019.104497]
19. Xinlin Chen, Shang Xue, Yaolan Lin, Jianguang Luo, Lingyi Kong. (2020) Immobilization of porcine pancreatic lipase onto a metal-organic framework, PPL@MOF: A new platform for efficient ligand discovery from natural herbs. ANALYTICA CHIMICA ACTA, 1099 (94). [PMID:31986282] [10.1016/j.aca.2019.11.042]
20. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu. (2019) Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods, 8 (9): (355). [PMID:31438605] [10.3390/foods8090355]
21. Xuexue Feng, Tielei Wu, Bingqing Yu, Yan Wang, Shian Zhong. (2017) Hydrophilic surface molecularly imprinted naringin prepared via reverse atom transfer radical polymerization with excellent recognition ability in a pure aqueous phase. RSC Advances, 7 (45): (28082-28091). [PMID:] [10.1039/C7RA00202E]
22. Songbai Liu, Yuanqing Fu, Si Nian. (2014) Buffering colour fluctuation of purple sweet potato anthocyanins to acidity variation by surfactants. FOOD CHEMISTRY, 162 (16). [PMID:24874351] [10.1016/j.foodchem.2014.04.029]
23. Shi Shen,Jingbo Wang,Qin Zhuo,Xi Chen,Tingting Liu,Shuang-Qing Zhang. (2018-05-09) Quantitative and Discriminative Evaluation of Contents of Phenolic and Flavonoid and Antioxidant Competence for Chinese Honeys from Different Botanical Origins.. Molecules (Basel, Switzerland), 23 ((5)): [PMID:29738446]

References

1. Min-Rui Tai, Hong-Wu Ji, Jian-Ping Chen, Xiao-Fei Liu, Bing-Bing Song, Sai-Yi Zhong, Aaqil Rifai, David R. Nisbet, Colin J. Barrow, Richard J. Williams, Rui Li. (2023) Biomimetic triumvirate nanogel complexes via peptide-polysaccharide-polyphenol self-assembly. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 251 (126232). [PMID:37562478] [10.1016/j.ijbiomac.2023.126232]
2. Hong-Qi Xia, Wanbing Chen, Diyang Qiu, Jiwu Zeng. (2023) Portable Microelectrochemical Sensors for Rapid and Sensitive Determination of Hesperidin in Citrus reticulate ‘Chachi’ Peel. MOLECULES, 28 (14): (5316). [PMID:37513189] [10.3390/molecules28145316]
3. Xiao-Hua Zhang, Xiang-Dong Qing, Jing-Jing Zheng, Yan Yu, Jiaojiao Huang, Chao Kang, Zhi Liu. (2023) Aqueous two-phase systems coupled with chemometrics-enhanced HPLC-DAD for simultaneous extraction and determination of flavonoids in honey. Food Chemistry-X, 19 (100766). [PMID:37780266] [10.1016/j.fochx.2023.100766]
4. Shengxiang Yi, Gaowei Zhang, Mingyan Liu, Wenjie Yu, Guohua Cheng, Liping Luo, Fangjian Ning. (2023) Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice. Nutrients, 15 (5): (1078). [PMID:36904078] [10.3390/nu15051078]
5. Pan Lixia, Ye Hangyu, Pi Xionge, Liu Wei, Wang Zhao, Zhang Yinjun, Zheng Jianyong. (2023) Effects of several flavonoids on human gut microbiota and its metabolism by in vitro simulated fermentation. Frontiers in Microbiology, 14 [PMID:36819019] [10.3389/fmicb.2023.1092729]
6. Hong-qi Xia, Diyang Qiu, Wanbing Chen, Genlin Mao, Jiwu Zeng. (2023) In situ formed and fully integrated laser-induced graphene electrochemical chips for rapid and simultaneous determination of bioflavonoids in citrus fruits. MICROCHEMICAL JOURNAL, 188 (108474). [PMID:] [10.1016/j.microc.2023.108474]
7. Chun Xiao Li, Fu Rong Wang, Bing Zhang, Ze Yuan Deng, Hong Yan Li. (2023) Stability and antioxidant activity of phenolic compounds during in vitro digestion. JOURNAL OF FOOD SCIENCE, 88 (2): (696-716). [PMID:36617678] [10.1111/1750-3841.16440]
8. Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo. (2023) Chemical composition and anti-inflammatory activities of Castanopsis honey. Food & Function, 14 (1): (250-261). [PMID:36484340] [10.1039/D2FO02233H]
9. Yu Bo, Luo Shiyu, Ding Yuhan, Gong Zijie, Nie Ting. (2022) Insights into glycosidic bond specificity of an engineered selective α-L-rhamnosidase N12-Rha via activity assays and molecular modelling. AMB Express, 12 (1): (1-14). [PMID:36370155] [10.1186/s13568-022-01489-5]
10. Dan Yu, Fei Liu, Changdong Zou, Xiao Yang. (2023) Municipal green waste promotes iron release from steelmaking slag in water. RESOURCES CONSERVATION AND RECYCLING, 188 (106722). [PMID:] [10.1016/j.resconrec.2022.106722]
11. Qi Quan, Wei Liu, Jiajing Guo, Meiling Ye, Juhua Zhang. (2022) Effect of Six Lactic Acid Bacteria Strains on Physicochemical Characteristics, Antioxidant Activities and Sensory Properties of Fermented Orange Juices. Foods, 11 (13): (1920). [PMID:35804736] [10.3390/foods11131920]
12. Ye Hangyu, Li Xiaojun, Li Luyuan, Zhang Yinjun, Zheng Jianyong. (2022) Homologous Expression and Characterization of α-L-rhamnosidase from Aspergillus niger for the Transformation of Flavonoids. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 194 (8): (3453-3467). [PMID:35366188] [10.1007/s12010-022-03894-9]
13. Hong-qi Xia, Tingting Gu, Ruiyi Fan, Jiwu Zeng. (2022) Comparative investigation of bioflavonoid electrocatalysis in 1D, 2D, and 3D carbon nanomaterials for simultaneous detection of naringin and hesperidin in fruits. RSC Advances, 12 (11): (6409-6415). [PMID:35424592] [10.1039/D1RA07217J]
14. Xiangrong Li, Ruonan Xu, Zeqing Cheng, Zhizhi Song, Ziyang Wang, Hanxiao Duan, Xinzhe Wu, Tianjun Ni. (2021) Comparative study on the interaction between flavonoids with different core structures and hyaluronidase. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 262 (120079). [PMID:34175762] [10.1016/j.saa.2021.120079]
15. Dan-Hua He, Yu-Fei Chen, Yi-Le Zhou, Shi-Bing Zhang, Ming Hong, Xianjun Yu, Su-Fen Wei, Xiang-Zhen Fan, Si-Yi Li, Qi Wang, Yongzhi Lu, Yong-Qiang Liu. (2021) Phytochemical library screening reveals betulinic acid as a novel Skp2-SCF E3 ligase inhibitor in non–small cell lung cancer. CANCER SCIENCE, 112 (8): (3218-3232). [PMID:34080260] [10.1111/cas.15005]
16. Lingrong Wen, Mingyang He, Chunxiao Yin, Yueming Jiang, Donghui Luo, Bao Yang. (2021) Phenolics in Citrus aurantium fruit identified by UHPLC-MS/MS and their bioactivities. LWT-FOOD SCIENCE AND TECHNOLOGY, 147 (111671). [PMID:] [10.1016/j.lwt.2021.111671]
17. Zhang Xiao-Hua, Ma Yi-Xin, Yi Chong, Qing Xiang-Dong, Liu Zhi, Zheng Jing-Jing, Lin Fang, Lv Tian-Feng. (2020) Chemometrics-enhanced HPLC–DAD as a rapid and interference-free strategy for simultaneous quantitative analysis of flavonoids in Chinese propolis. EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 246 (10): (1909-1918). [PMID:] [10.1007/s00217-020-03543-7]
18. Hui Guo, Yunfei Chen, Na Song, Xinyi Yang, Shen Yao, Junqing Qian. (2020) Screening of lipase inhibitors from bamboo leaves based on the magnetic ligand fishing combined with HPLC/MS. MICROCHEMICAL JOURNAL, 153 (104497). [PMID:] [10.1016/j.microc.2019.104497]
19. Xinlin Chen, Shang Xue, Yaolan Lin, Jianguang Luo, Lingyi Kong. (2020) Immobilization of porcine pancreatic lipase onto a metal-organic framework, PPL@MOF: A new platform for efficient ligand discovery from natural herbs. ANALYTICA CHIMICA ACTA, 1099 (94). [PMID:31986282] [10.1016/j.aca.2019.11.042]
20. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu. (2019) Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods, 8 (9): (355). [PMID:31438605] [10.3390/foods8090355]
21. Xuexue Feng, Tielei Wu, Bingqing Yu, Yan Wang, Shian Zhong. (2017) Hydrophilic surface molecularly imprinted naringin prepared via reverse atom transfer radical polymerization with excellent recognition ability in a pure aqueous phase. RSC Advances, 7 (45): (28082-28091). [PMID:] [10.1039/C7RA00202E]
22. Songbai Liu, Yuanqing Fu, Si Nian. (2014) Buffering colour fluctuation of purple sweet potato anthocyanins to acidity variation by surfactants. FOOD CHEMISTRY, 162 (16). [PMID:24874351] [10.1016/j.foodchem.2014.04.029]
23. Shi Shen,Jingbo Wang,Qin Zhuo,Xi Chen,Tingting Liu,Shuang-Qing Zhang. (2018-05-09) Quantitative and Discriminative Evaluation of Contents of Phenolic and Flavonoid and Antioxidant Competence for Chinese Honeys from Different Botanical Origins.. Molecules (Basel, Switzerland), 23 ((5)): [PMID:29738446]

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