HBDDE - ≥97%, high purity , CAS No.154675-18-0

Item Number

H275628

Grouped product items
SKU	Size	Availability	Price	Qty
H275628-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$214.90
H275628-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$966.90

Selective PKCα and PKCγ inhibitor

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Basic Description

Synonyms	6,6'-Bis(methoxymethyl)[1,1'-biphenyl]-2,2',3,3',4,4'-hexol \| KBio3_000850 \| SCHEMBL1272421 \| Bio2_000868 \| HMS1792G17 \| KBio2_003023 \| IDI1_002143 \| J-009130 \| KBio2_000455 \| KBioSS_000455 \| HBDDE - CAS 154675-18-0 \| BiomolKI_000067 \| Hhbpdde \| HMS3403G1
Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	PKCα and PKCγ inhibitor (IC 50 values are 43 and 50 μM respectively). δ, βI and βII isotypes are not affected. Inducer of apoptosis. Active in vivo .
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Names and Identifiers

IUPAC Name	5-(methoxymethyl)-4-[2,3,4-trihydroxy-6-(methoxymethyl)phenyl]benzene-1,2,3-triol
INCHI	InChI=1S/C16H18O8/c1-23-5-7-3-9(17)13(19)15(21)11(7)12-8(6-24-2)4-10(18)14(20)16(12)22/h3-4,17-22H,5-6H2,1-2H3
InChi Key	NEBCAMAQXZIVRE-UHFFFAOYSA-N
Canonical SMILES	COCC1=CC(=C(C(=C1C2=C(C(=C(C=C2COC)O)O)O)O)O)O
Isomeric SMILES	COCC1=CC(=C(C(=C1C2=C(C(=C(C=C2COC)O)O)O)O)O)O
PubChem CID	3568
Molecular Weight	338.3

References

1. Najibi M et al.. (2016) An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense.. Cell Rep, 15 (8): (1728-42). [PMID:27184844]
2. Goode DJ & Molliver DC. (2019) Phospho-substrate profiling of Epac-dependent protein kinase C activity.. Mol Cell Biochem, 456 (1-2): (167-178). [PMID:30739223]

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Basic Description