Selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50= 15 nM). Displays no activity at other nuclear receptors at concentrations up to 1μM. Improves hyperglycaemia and hyperlipidemia in diabetic db/db mice. Shown to suppress autophagy in nutri
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of Farnesoid X receptor
Product Description
GW4064 is an agonist of farnesoid X receptor (FXR) with EC50 of 65 nM in CV1 cell line and displays no activity at other nuclear receptors at concentrations up to 1 μM.
1.Zhiyuan Meng, Sen Yan, Wei Sun, Jin Yan, Miaomiao Teng, Ming Jia, Sinuo Tian, Zhiqiang Zhou, Wentao Zhu. (2023) Chlorothalonil induces obesity in mice by regulating host gut microbiota and bile acids metabolism via FXR pathways. JOURNAL OF HAZARDOUS MATERIALS, 452 (131310). [PMID:37003002][10.1016/j.jhazmat.2023.131310]
References
1.Zhiyuan Meng, Sen Yan, Wei Sun, Jin Yan, Miaomiao Teng, Ming Jia, Sinuo Tian, Zhiqiang Zhou, Wentao Zhu. (2023) Chlorothalonil induces obesity in mice by regulating host gut microbiota and bile acids metabolism via FXR pathways. JOURNAL OF HAZARDOUS MATERIALS, 452 (131310). [PMID:37003002][10.1016/j.jhazmat.2023.131310]
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E23101128