| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| G348660-5mg | 5mg | 2 | $459.90 |
a non-hydrolyzable GTP analog ARF (ADP-ribosylation factor) activator.
| Synonyms | GPP(NH)p | GMP-PNP | guanosine 5'-[beta,gamma-imido]triphosphate trisodium salt | Q27147790 | guanylyl imidodiphosphate | PD017901 | Guanosine 5'-[beta,gamma-imido]triphosphate trisodium salt hydrate, >=85% (HPLC), powder | trisodium;[[(2R,3S,4R,5R)-5-(2- |
|---|---|
| Specifications & Purity | ≥85% |
| Biochemical and Physiological Mechanisms | Guanosine 5′-[ß,γ-imino]triphosphate binds to G protein and activates it irreversibly. Since the cycle of GTP binding, hydrolysis and release is necessary to initiate protein transfer across the endoplasmic reticulum, this non-hydrolyzable analog of GTP i |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Note | Guanylyl Imidodiphosphate is soluble is water, 50 mg/ml |
| Product Description | Guanylyl Imidodiphosphate is the preferred GTP analog to activate ADP-ribosylation factor. Guanylyl Imidodiphosphate binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, Guanylyl Imidodiphosphate is often used in studies of protein synthesis. Guanylyl Imidodiphosphate has linkage to Non-hydrolyzable analogs of GTP. |
| Pubchem Sid | 504773325 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773325 |
| IUPAC Name | trisodium;[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-[[hydroxy(oxido)phosphoryl]amino]phosphinate |
| INCHI | InChI=1S/C10H17N6O13P3.3Na/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22;;;/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1 |
| InChi Key | QGJNRMUNXAROIT-CYCLDIHTSA-K |
| Canonical SMILES | [Na+].[Na+].[Na+].Nc1nc(O)c2ncn([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)NP(O)([O-])=O)[C@@H](O)[C@H]3O)c2n1 |
| Isomeric SMILES | C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)(NP(=O)(O)[O-])[O-])O)O)N=C(NC2=O)N.[Na+].[Na+].[Na+] |
| WGK Germany | 3 |
| Molecular Weight | 588.14 (anhydrous basis) |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
C2507428