GSK690693 - ≥98%, high purity , Protein kinase C (PKC) inhibitor, CAS No.937174-76-0, Protein kinase C (PKC) inhibitor

Item Number

G127527

Grouped product items
SKU	Size	Availability	Price
G127527-5mg	5mg	2	$117.90
G127527-10mg	10mg	2	$166.90
G127527-50mg	50mg	2	$533.90
G127527-100mg	100mg	2	$855.90

Novel ATP-competitive pan-Akt kinase inhibitor

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Basic Description

Synonyms	(R)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-yl-MeO)-1H-imidazo[4,5-c]pyridin-4-yl)-2-Me-but-3-yn-2-ol \| UNII-GWH480321B \| AKOS015904356 \| NCGC00263181-01 \| (-)-4-(2-(4-AMINO-1,2,5-OXADIAZOL-3-YL)-1-ETHYL-7-((3S)-3-PIPERIDINYLMETHOXY)-1H
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	GSK-690693 is an ATP-competitive pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM for Akt1, 2 and 3 respectively). GSK-690693 also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC50 < 100 nM). GSK-690693 displays antiprolifer
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Protein kinase C (PKC) inhibitor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Novel ATP-competitive pan-Akt kinase inhibitor. GSK690693 has been used in western blotting and immunoprecipitations.

Names and Identifiers

Pubchem Sid	504768503
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504768503
IUPAC Name	4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[[(3S)-piperidin-3-yl]methoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol
INCHI	InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1
InChi Key	KGPGFQWBCSZGEL-ZDUSSCGKSA-N
Canonical SMILES	CCN1C2=C(C(=NC=C2OCC3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N
Isomeric SMILES	CCN1C2=C(C(=NC=C2OC[C@H]3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N
WGK Germany	3
PubChem CID	16725726
Molecular Weight	425.48

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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4 results found

Lot Number	Certificate Type	Date	Item
K2228299	Certificate of Analysis	Sep 12, 2024	G127527
K2228301	Certificate of Analysis	Sep 12, 2024	G127527
K2228345	Certificate of Analysis	Sep 12, 2024	G127527
K2228346	Certificate of Analysis	Sep 12, 2024	G127527

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
WGK Germany	3

References

1. Rhodes N, Heerding DA, Duckett DR, Eberwein DJ, Knick VB, Lansing TJ, McConnell RT, Gilmer TM, Zhang SY, Robell K et al.. (2008) Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity.. Cancer Res, 68 (7): (2366-74). [PMID:18381444] [10.1021/op500134e]
2. Heerding DA, Rhodes N, Leber JD, Clark TJ, Keenan RM, Lafrance LV, Li M, Safonov IG, Takata DT, Venslavsky JW et al.. (2008) Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.. J Med Chem, 51 (18): (5663-79). [PMID:18800763] [10.1021/op500134e]

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Basic Description