GSK 583 - ≥98%(HPLC), high purity , CAS No.1346547-00-9, Inhibitor of receptor interacting serine/threonine kinase 2

Item Number

G286537

Grouped product items
SKU	Size	Availability	Price
G286537-5mg	5mg	3	$165.90
G286537-10mg	10mg	5	$260.90
G286537-25mg	25mg	4	$587.90
G286537-50mg	50mg	3	$890.90

Potent RIPK2 inhibitor and cell permeable

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Basic Description

Synonyms	GSK 583 \| GSK-2616583A
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent RIPK2 inhibitor (IC50values are 2 and 5 nM at rat and human kinases, respectively). Displays selectivity for RIP2K over p38α, VEGFR2 and a panel of 300 kinases. Exhibits some inhibition at BRK and Aurora A. Also displays similar binding affinity, b
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of receptor interacting serine/threonine kinase 2
Product Description	GSK583 is a highly potent, orally active and selective inhibitor of RIP2 Kinase, with IC50 of 5 nM. GSK583 inhibits both TNF-α and IL-6 production with an IC50 value of 200 nM.

Names and Identifiers

Pubchem Sid	488202097
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488202097
IUPAC Name	6-tert-butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine
INCHI	InChI=1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)
InChi Key	XLOGLWKOHPIJLV-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=NNC4=C3C=C(C=C4)F
Isomeric SMILES	CC(C)(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=NNC4=C3C=C(C=C4)F
PubChem CID	67469084
MeSH Entry Terms	6-(tert-butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine;GSK583
Molecular Weight	398.45

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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8 results found

Lot Number	Certificate Type	Date	Item
D2301304	Certificate of Analysis	Feb 06, 2023	G286537
D2301307	Certificate of Analysis	Feb 06, 2023	G286537
D2301308	Certificate of Analysis	Feb 06, 2023	G286537
D2301336	Certificate of Analysis	Feb 06, 2023	G286537
D2301339	Certificate of Analysis	Feb 06, 2023	G286537
D2301340	Certificate of Analysis	Feb 06, 2023	G286537
D2301341	Certificate of Analysis	Feb 06, 2023	G286537
D2301342	Certificate of Analysis	Feb 06, 2023	G286537

References

1. Haile PA, Votta BJ, Marquis RW, Bury MJ, Mehlmann JF, Singhaus Jr R, Charnley AK, Lakdawala AS, Convery MA, Lipshutz DB et al.. (2016) The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.. J Med Chem, 59 (10): (4867-80). [PMID:27109867] [10.1021/op500134e]

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Basic Description