GSK-3 Inhibitor XIII - 98%, high purity , CAS No.404828-08-6, Inhibitor of aurora kinase A;Inhibitor of glycogen synthase kinase 3 beta;Inhibitor of SRC proto-oncogene; non-receptor tyrosine kinase

Item Number
G338805
Grouped product items
SKUSizeAvailabilityPrice Qty
G338805-1mg
1mg
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$150.90
G338805-5mg
5mg
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$438.90
G338805-10mg
10mg
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$790.90
G338805-25mg
25mg
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$1,777.90
G338805-50mg
50mg
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$3,199.90

an ATP-binding site inhibitor of GSK-3

Basic Description

Synonyms(5-Methyl-1H-pyrazol-3-yl)-(2-phenylquinazolin-4-yl)amine
Specifications & PurityMoligand™, ≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of aurora kinase A;Inhibitor of glycogen synthase kinase 3 beta;Inhibitor of SRC proto-oncogene; non-receptor tyrosine kinase
Product Description

GSK-3 Inhibitor XIII is an aminopyrazole compound that acts as an ATP-binding site inhibitor of GSK-3. Studies suggest that GSK-3 is a multifunctional serine/threonine kinase involved in estrogen and androgen receptor stability by phosphorylation. GSK-3 can bind to androgen receptors forming complexes in the cytoplasm and nucleus, so inhibition by GSK-3 Inhibitor XIII, will result in a rapid nuclear export of endogenous androgen receptors thus reducing receptors for the enzyme to bind to.

AI Insight

Product Properties

Ki DataGSK-3: Ki= 24 nM; Tyrosine-protein kinase SRC: Ki= 81 nM (human)

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Canonical SMILES CC1=CC(=NN1)NC2=NC(=NC3=CC=CC=C32)C4=CC=CC=C4
Isomeric SMILES CC1=CC(=NN1)NC2=NC(=NC3=CC=CC=C32)C4=CC=CC=C4
PubChem CID 6419766
Molecular Weight 305.3

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Related Documents

Reviews

Customer Reviews

References

1. Bebbington D, Binch H, Charrier JD, Everitt S, Fraysse D, Golec J, Kay D, Knegtel R, Mak C, Mazzei F et al..  (2009)  The discovery of the potent aurora inhibitor MK-0457 (VX-680)..  Bioorg Med Chem Lett,  19  (13): (3586-92).  [PMID:19447622] [10.1021/op500134e]

Solution Calculators