GSK 2239633A - ≥98%(HPLC), high purity , CAS No.1240516-71-5, Antagonist of CCR4;Antagonist of CCR5

Item Number

G286917

Grouped product items
SKU	Size	Availability	Price
G286917-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$37.90
G286917-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$154.90
G286917-10mg	10mg	2	$199.90
G286917-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$578.90
G286917-50mg	50mg	1	$699.90

Potent CCR4 antagonist

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Basic Description

Synonyms	Propanamide, N-((3-((3-(((5-chloro-2-thienyl)sulfonyl)amino)-4-methoxy-1H-indazol-1-yl)methyl)phenyl)methyl)-2-hydroxy-2-methyl- \| GTPL10416 \| A929738 \| BCP29621 \| UNII-07ODS257BP \| MS-30054 \| SCHEMBL358731 \| AKOS040733312 \| N-((3-((3-((5-Chloro-2-thienyl
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent CCR4 antagonist (pIC50= 7.83 in a35S-GTPγS competition assay). Inhibits thymus activation-regulated chemokine (TARC) -induced F-actin polymerization in human whole blood.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of CCR4;Antagonist of CCR5
Product Description	GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96 ± 0.11.

Names and Identifiers

Pubchem Sid	504770823
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504770823
IUPAC Name	N-[[3-[[3-[(5-chlorothiophen-2-yl)sulfonylamino]-4-methoxyindazol-1-yl]methyl]phenyl]methyl]-2-hydroxy-2-methylpropanamide
INCHI	InChI=1S/C24H25ClN4O5S2/c1-24(2,31)23(30)26-13-15-6-4-7-16(12-15)14-29-17-8-5-9-18(34-3)21(17)22(27-29)28-36(32,33)20-11-10-19(25)35-20/h4-12,31H,13-14H2,1-3H3,(H,26,30)(H,27,28)
InChi Key	YTEVTHHGQMUPHC-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C(=O)NCC1=CC(=CC=C1)CN2C3=C(C(=CC=C3)OC)C(=N2)NS(=O)(=O)C4=CC=C(S4)Cl)O
Isomeric SMILES	CC(C)(C(=O)NCC1=CC(=CC=C1)CN2C3=C(C(=CC=C3)OC)C(=N2)NS(=O)(=O)C4=CC=C(S4)Cl)O
PubChem CID	46861584
Molecular Weight	549.06

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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7 results found

Lot Number	Certificate Type	Date	Item
K2316172	Certificate of Analysis	Nov 07, 2023	G286917
K2316173	Certificate of Analysis	Nov 07, 2023	G286917
K2316336	Certificate of Analysis	Nov 07, 2023	G286917
K2316337	Certificate of Analysis	Nov 07, 2023	G286917
K2316338	Certificate of Analysis	Nov 07, 2023	G286917
K2316339	Certificate of Analysis	Nov 07, 2023	G286917
K2316340	Certificate of Analysis	Nov 07, 2023	G286917

References

1. Procopiou PA, Barrett JW, Barton NP, Begg M, Clapham D, Copley RC, Ford AJ, Graves RH, Hall DA, Hancock AP et al.. (2013) Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.. J Med Chem, 56 (5): (1946-60). [PMID:23409871] [10.1021/op500134e]
2. Cahn A, Hodgson S, Wilson R, Robertson J, Watson J, Beerahee M, Hughes SC, Young G, Graves R, Hall D et al.. (2013) Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study.. BMC Pharmacol Toxicol, 14 (13): (14). [PMID:23448278] [10.1186/2050-6511-14-14]

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Basic Description