| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| G288522-5mg | 5mg | 3 | $133.90 | |
| G288522-10mg | 10mg | 3 | $205.90 | |
| G288522-25mg | 25mg | 2 | $461.90 | |
| G288522-50mg | 50mg | 2 | $862.90 |
Potent LXR antagonist
| Synonyms | GSK2033 | 2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide |
|---|---|
| Specifications & Purity | Moligand™, ≥96% |
| Biochemical and Physiological Mechanisms | Potent LXR antagonist (pIC50= 7.5). Enhances T-cell proliferation and blocksT 0901317-antiproliferative activity on T-cells. Cell permeable. |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Action Type | ANTAGONIST |
| Mechanism of action | Antagonist of Liver X receptor-α;Antagonist of Liver X receptor-β |
| Product Description | Introduction: GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively. |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Pubchem Sid | 504770678 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504770678 |
| IUPAC Name | 2,4,6-trimethyl-N-[[4-(3-methylsulfonylphenyl)phenyl]methyl]-N-[[5-(trifluoromethyl)furan-2-yl]methyl]benzenesulfonamide |
| INCHI | InChI=1S/C29H28F3NO5S2/c1-19-14-20(2)28(21(3)15-19)40(36,37)33(18-25-12-13-27(38-25)29(30,31)32)17-22-8-10-23(11-9-22)24-6-5-7-26(16-24)39(4,34)35/h5-16H,17-18H2,1-4H3 |
| InChi Key | PSOXOVKYGWBTPB-UHFFFAOYSA-N |
| Canonical SMILES | CC1=CC(=C(C(=C1)C)S(=O)(=O)N(CC2=CC=C(C=C2)C3=CC(=CC=C3)S(=O)(=O)C)CC4=CC=C(O4)C(F)(F)F)C |
| Isomeric SMILES | CC1=CC(=C(C(=C1)C)S(=O)(=O)N(CC2=CC=C(C=C2)C3=CC(=CC=C3)S(=O)(=O)C)CC4=CC=C(O4)C(F)(F)F)C |
| PubChem CID | 46203250 |
| MeSH Entry Terms | 2,4,6-trimethyl-N-((3'-(methylsulfonyl)-4-biphenylyl)methyl)-N-((5-(trifluoromethyl)-2-furanyl)methyl)benzenesulfonamide;GSK 2033;GSK-2033;GSK2033 |
| Molecular Weight | 591.66 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 K2214420 | Certificate of Analysis | Jul 07, 2022 | G288522 |
| K2214421 | Certificate of Analysis | Jul 07, 2022 | G288522 |
| K2214422 | Certificate of Analysis | Jul 07, 2022 | G288522 |
| K2214423 | Certificate of Analysis | Jul 07, 2022 | G288522 |
| L2419298 | Certificate of Analysis | Jul 07, 2022 | G288522 |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
| RIDADR | NONHforallmodesoftransport |
