GSK 2018682 - ≥98%(HPLC), high purity , CAS No.1034688-30-6, Agonist of S1P 1 receptor;Agonist of S1P 5 receptor

Item Number

G288907

Grouped product items
SKU	Size	Availability	Price
G288907-5mg	5mg	3	$63.90
G288907-10mg	10mg	3	$98.90
G288907-25mg	25mg	2	$222.90
G288907-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$414.90
G288907-100mg	100mg	2	$741.90

S1P1and S1P5agonist

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Basic Description

Synonyms	4-[4-[5-(5-chloro-6-propan-2-yloxypyridin-3-yl)-1,2,4-oxadiazol-3-yl]indol-1-yl]butanoic acid \| EX-A1725 \| AKOS037648495 \| BCP31201 \| GTPL11311 \| BS-14195 \| 1034688-30-6 \| AC-30351 \| Q27284898 \| 1H-Indole-1-butanoic acid, 4-(5-(5-chloro-6-(1-methylethoxy)
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Sphingosine-1-phosphate receptor 1 (S1P1) and 5 (S1P5) agonist.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of S1P 1 receptor;Agonist of S1P 5 receptor

Names and Identifiers

Pubchem Sid	504769925
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504769925
IUPAC Name	4-[4-[5-(5-chloro-6-propan-2-yloxypyridin-3-yl)-1,2,4-oxadiazol-3-yl]indol-1-yl]butanoic acid
INCHI	InChI=1S/C22H21ClN4O4/c1-13(2)30-22-17(23)11-14(12-24-22)21-25-20(26-31-21)16-5-3-6-18-15(16)8-10-27(18)9-4-7-19(28)29/h3,5-6,8,10-13H,4,7,9H2,1-2H3,(H,28,29)
InChi Key	NFIGDBFIDKDNIG-UHFFFAOYSA-N
Canonical SMILES	CC(C)OC1=C(C=C(C=N1)C2=NC(=NO2)C3=C4C=CN(C4=CC=C3)CCCC(=O)O)Cl
Isomeric SMILES	CC(C)OC1=C(C=C(C=N1)C2=NC(=NO2)C3=C4C=CN(C4=CC=C3)CCCC(=O)O)Cl
PubChem CID	24988201
Molecular Weight	440.88

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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5 results found

Lot Number	Certificate Type	Date	Item
G2206164	Certificate of Analysis	Apr 03, 2025	G288907
G2206173	Certificate of Analysis	Apr 03, 2025	G288907
G2206174	Certificate of Analysis	Apr 03, 2025	G288907
G2206175	Certificate of Analysis	Apr 03, 2025	G288907
G2206176	Certificate of Analysis	Apr 03, 2025	G288907

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection.

References

1. Xu J, Gray F, Henderson A, Hicks K, Yang J, Thompson P, Oliver J. (2014) Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine-1-phosphate receptor modulator, in healthy volunteers.. Clin Pharmacol Drug Dev, 3 (3): (170-8). [PMID:27128606] [10.1021/op500134e]

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Basic Description