Gemcitabine hydrochloride - 10mM in Water, high purity , CAS No.122111-03-9, DNA polymerase (alpha/delta/epsilon) inhibitor

Item Number

G420950

Grouped product items
SKU	Size	Availability	Price	Qty
G420950-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$28.90

Potent, specific deoxycytidine analog

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Basic Description

Synonyms	GEMCITABINE HYDROCHLORIDE \| 122111-03-9 \| Gemcitabine HCl \| Gemzar \| LY188011 hydrochloride \| 2'-Deoxy-2',2'-difluorocytidine monohydrochloride \| Cytidine, 2'-deoxy-2',2'-difluoro-, monohydrochloride \| LY-188011 \| Gemcitabine (Hydrochloride) \| UNII-U347PV74IL \| Gemcitabine (
Specifications & Purity	10mM in Water
Biochemical and Physiological Mechanisms	Gemcitabine hydrochloride is used for treatment of non-small cell lung cancer, pancreatic cancer, mammary cancer, ovarian cancer, bladder cancer, nasopharyngeal carcinoma and non-Hodgkin's lymphoma.Deoxycytidine analog that inhibits DNA synthesis. Metabol
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	DNA polymerase (alpha/delta/epsilon) inhibitor
Product Description	Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.This product is only used for scientific research.

Names and Identifiers

IUPAC Name	4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride
INCHI	InChI=1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
InChi Key	OKKDEIYWILRZIA-OSZBKLCCSA-N
Canonical SMILES	Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F
Isomeric SMILES	C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F.Cl
WGK Germany	3
RTECS	HA3840000
PubChem CID	60749
Molecular Weight	299.66
Reaxy-Rn	5386970

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Danger
Hazard Statements	H360:May damage fertility or the unborn child
Precautionary Statements	P201:Obtain special instructions before use. P308+P313:IF exposed or concerned: Get medical advice/attention.
WGK Germany	3
RTECS	HA3840000
Reaxy-Rn	5386970
Merck Index	4386

Citations of This Product

1. Zhimei Wang, Yuehuan Zhang, Qing Chen, Xin Xiao, Carl Redshaw. (2023) Preparation of pelargonic acid vesicles and sustained drug release. Canadian Journal of Chemistry, 101 (2): [PMID:] [10.1139/cjc-2022-0075]
2. Yadong Tang,Boxin Huang,Yuqin Dong,Wenlong Wang,Xi Zheng,Wei Zhou,Kun Zhang,Zhiyun Du. (2017-06-07) Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy.. Journal of biomaterials science. Polymer edition, 28 ((14)): (1603-1616). [PMID:28583017]

References

1. Zhimei Wang, Yuehuan Zhang, Qing Chen, Xin Xiao, Carl Redshaw. (2023) Preparation of pelargonic acid vesicles and sustained drug release. Canadian Journal of Chemistry, 101 (2): [PMID:] [10.1139/cjc-2022-0075]
2. Yadong Tang,Boxin Huang,Yuqin Dong,Wenlong Wang,Xi Zheng,Wei Zhou,Kun Zhang,Zhiyun Du. (2017-06-07) Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy.. Journal of biomaterials science. Polymer edition, 28 ((14)): (1603-1616). [PMID:28583017]

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Basic Description