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Gemcitabine - ≥99%, high purity , CAS No.95058-81-4, Inhibitor of ribonucleotide reductase catalytic subunit M1;Inhibitor of ribonucleotide reductase regulatory subunit M2

21 Citations

Moligand™

≥99%

CAS#: 95058-81-4
Molecular Weight: 263.2
MDL number: MFCD00869720
PubChem CID: 60750
PubChem SID: 504753715

Item Number

G127944

Grouped product items
SKU	Size	Availability	Price
G127944-50mg	50mg	3	$9.90
G127944-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$11.90
G127944-250mg	250mg	3	$18.90
G127944-1g	1g	2	$56.90
G127944-5g	5g	1	$199.90
G127944-10g	10g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$319.90
G127944-25g	25g	3	$629.90
G127944-100g	100g	2	$1,499.90

Cytidine analog. Antimetabolite.

View related series

Apoptosis (0) Autophagy (0) Cell Cycle/DNA Damage (0) DNA/RNA Synthesis (0) Nucleoside Antimetabolite/Analog (0) Nucleosides (0) ribonucleotide reductase catalytic subunit M1 Inhibitor (0) ribonucleotide reductase regulatory subunit M2 Inhibitor (0)

Basic Description

Synonyms	2'-Deoxy-2',2'-difluorocytidine \| 2',2'-Difluorodeoxycytidine
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Gemcitabine is a widely used antitumor agents in both clinics and research labs. It is an antineoplastic agent and antimetabolite. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCT
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of ribonucleotide reductase catalytic subunit M1;Inhibitor of ribonucleotide reductase regulatory subunit M2
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	2'-Deoxy-2',2'-difluorocytidine is an irreversible inactivator of R1 and R2 (ribonucleoside diphosphate reductase, RDPR) from Escherichia coli. Soluble in ethanol (~0.25 mg/ml), DMSO (15 mg/ml at 25 °C), DMF (~0.1 mg/ml), water (<1 mg/ml at 25 °C), and PBS pH 7.2 (~2 mg/ml). An irreversible inactivator of bacterial ribonucleoside diphosphate reductase.

AI Insight

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504753715
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504753715
IUPAC Name	4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
INCHI	InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1
InChi Key	SDUQYLNIPVEERB-QPPQHZFASA-N
Canonical SMILES	C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F
Isomeric SMILES	C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F
Alternate CAS	122111-03-9
PubChem CID	60750
Molecular Weight	263.2

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

32 results found

Lot Number	Certificate Type	Date	Item
E2330122	Certificate of Analysis	Mar 05, 2025	G127944
F2301019	Certificate of Analysis	Mar 04, 2025	G127944
K2404403	Certificate of Analysis	Jul 05, 2024	G127944
G2426375	Certificate of Analysis	Jul 05, 2024	G127944
G2426376	Certificate of Analysis	Jul 05, 2024	G127944
G2426392	Certificate of Analysis	Jul 05, 2024	G127944
F2223305	Certificate of Analysis	May 09, 2024	G127944
F2223277	Certificate of Analysis	May 09, 2024	G127944
F2223304	Certificate of Analysis	Apr 03, 2024	G127944
D2412470	Certificate of Analysis	Mar 28, 2024	G127944
D2412472	Certificate of Analysis	Mar 28, 2024	G127944
D2412468	Certificate of Analysis	Mar 28, 2024	G127944
D2412466	Certificate of Analysis	Mar 28, 2024	G127944
D2412464	Certificate of Analysis	Mar 28, 2024	G127944
F2419055	Certificate of Analysis	Mar 28, 2024	G127944
G2408023	Certificate of Analysis	Mar 28, 2024	G127944
C2421406	Certificate of Analysis	Mar 11, 2024	G127944
L2318466	Certificate of Analysis	Dec 01, 2023	G127944
L2318465	Certificate of Analysis	Dec 01, 2023	G127944
L2318468	Certificate of Analysis	Dec 01, 2023	G127944
L2318467	Certificate of Analysis	Dec 01, 2023	G127944
L2106531	Certificate of Analysis	Sep 19, 2023	G127944
L2106533	Certificate of Analysis	Sep 19, 2023	G127944
L2106534	Certificate of Analysis	Sep 19, 2023	G127944
L2106600	Certificate of Analysis	Sep 19, 2023	G127944
C2130218	Certificate of Analysis	Jan 13, 2023	G127944
C2130220	Certificate of Analysis	Jan 13, 2023	G127944
K1819040	Certificate of Analysis	Jul 18, 2022	G127944
K2327045	Certificate of Analysis	Jun 01, 2022	G127944
H2316110	Certificate of Analysis	Jun 01, 2022	G127944
G2311070	Certificate of Analysis	Jun 01, 2022	G127944
F2223303	Certificate of Analysis	Jun 01, 2022	G127944

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Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H312:Harmful in contact with skin H360:May damage fertility or the unborn child H340:May cause genetic defects H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help.
Merck Index	4386

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FAQs and Articles

FAQ

Nucleotide Synthesis in Cancer Cells

Categories: Technical articles

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nucleotide Glycolysis Ribose 5-phosphate TCA cycle

Metabolic signaling pathway

Categories: Technical articles

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Carbohydrate metabolism Lipid metabolism Glutamic acid metabolism Nucleotide metabolism

Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Dongchao Xu, Ajuan Liu, Qiang Liu, Hongchen Zhang, Mengyao Tian, Ying Bian, Xiaofeng Zhang, Meidan Ying, Hongzhang Shen. (2023) Cucurbitacin C suppresses the progression of pancreatic ductal adenocarcinoma via inhibition of the cGMP-PKG-VASP axis. BIOCHEMICAL PHARMACOLOGY, 217 (3): (115810). [PMID:37717690] [10.1016/j.bcp.2023.115810]
2. Yifan Luo, Chao Li, Yiwen Zhang, Peixin Liu, Hongyi Chen, Zhenhao Zhao, Yu Wang, Zheng Zhou, Haolin Song, Boyu Su, Chufeng Li, Xuwen Li, Tongyu Zhang, Haoyu You, Yuxing Wu, Zonghua Tian, Shilin Zhang, Yun Guo, Hongrui Fan, Qinjun Chen, Chen Jiang, Tao Sun. (2023) Gradient tumor microenvironment-promoted penetrating micelles for hypoxia relief and immunosuppression reversion in pancreatic cancer treatment. Acta Biomaterialia, [PMID:37276955] [10.1016/j.actbio.2023.05.047]
3. Nan Zhang, Junwei Zhang, Weiqi Cui, Deqiao Wu, Jingxian Zhang, Bo Wei, Lingbo Qu, Xia Xu. (2023) Artemisia argyi H.Lév. & Vaniot essential oil induces ferroptosis in pancreatic cancer cells via up-regulation of TFR1 and depletion of γ-glutamyl cycle. FITOTERAPIA, 168 (105522). [PMID:37169131] [10.1016/j.fitote.2023.105522]
4. Zhuo Yao, Qida Hu, Piaopiao Jin, Bowen Li, Yong Huang, Fu Zhang, Meng Wang, Junming Huang, Jing Huang, Shiyi Shao, Xinyu Zhao, Yuan Ping, Tingbo Liang. (2023) A Self-Assembly Combined Nano-Prodrug to Overcome Gemcitabine Chemo-Resistance of Pancreatic Tumors. ADVANCED FUNCTIONAL MATERIALS, (2214598). [PMID:] [10.1002/adfm.202214598]
5. Fu Zhang, Zhuo Yao, Piaopiao Jin, Mengqiu Xu, Qida Hu, Yuxuan Chen, Risheng Que, Tingbo Liang. (2023) A tumor microenvironment-stimuli responsive nano-prodrug for overcoming gemcitabine chemoresistance by co-delivered miRNA-21 modulator. Biomedical Materials, 18 (3): (35010). [PMID:36990101] [10.1088/1748-605X/acc8ac]
6. Fu Zhang, Qida Hu, Bowen Li, Yong Huang, Meng Wang, Shiyi Shao, Honglin Tang, Zhuo Yao, Yuan Ping, Tingbo Liang. (2023) A biomimetic nanodrug for enhanced chemotherapy of pancreatic tumors. JOURNAL OF CONTROLLED RELEASE, 354 (835). [PMID:36627026] [10.1016/j.jconrel.2023.01.007]
7. Hao Chi, Sheng Tian, Xiu Li, Yuchu Chen, Qiumin Xu, Qixiao Wang, Wenwan Shi, Michael Adu-Frimpong, Shanshan Tong. (2023) Construction of lipid raft-coupled agarose gels as bioaffinity chromatography materials and validation with tropomyosin-related kinase A-targeted drugs. JOURNAL OF CHROMATOGRAPHY A, 1691 (463803). [PMID:36731332] [10.1016/j.chroma.2023.463803]
8. Yaowei Guo, Jin Liu, Qinglin Tang, Cuicui Li, Yanying Zhang, Yao Wang, Yanxin Wang, Yupeng Bi, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore, Jianguo Tang. (2022) Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (12): (6597). [PMID:35743042] [10.3390/ijms23126597]
9. Yuting Zhu, Shanhao Han, Jianhui Li, Hongwei Gao, Bo Dong. (2022) Aqueous Extract of Sea Squirt (Halocynthia roretzi) with Potent Activity against Human Cancer Cells Acts Synergistically with Doxorubicin. Marine Drugs, 20 (5): (284). [PMID:35621935] [10.3390/md20050284]
10. Chen Ting-ting, Yuan Ming-ming, Tao Yu-mei, Ren Xiao-yan, Li Sufen. (2022) Engineering of Self-assembly Polymers Encapsulated with Dual Anticancer Drugs for the Treatment of Endometrial Cancer. JOURNAL OF CLUSTER SCIENCE, 33 (6): (2661-2671). [PMID:] [10.1007/s10876-021-02175-5]
11. Yingjie Kong, Yeneng Dai, Dashan Qi, Wenyu Du, Haiyang Ni, Fan Zhang, Honghai Zhao, Qingming Shen, Meixing Li, Quli Fan. (2021) Injectable and Thermosensitive Liposomal Hydrogels for NIR-II Light-Triggered Photothermal-Chemo Therapy of Pancreatic Cancer. ACS Applied Bio Materials, 4 (10): (7595–7604). [PMID:35006703] [10.1021/acsabm.1c00864]
12. Xiaoyu Xu, Zishan Zeng, Xin Ding, Ting Shan, Qiuxing Liu, Meixu Chen, Jie Chen, Meng Xia, Yuanfeng He, Zeqian Huang, Yanjuan Huang, Chunshun Zhao. (2021) Reactive oxygen species-activatable self-amplifying Watson-Crick base pairing-inspired supramolecular nanoprodrug for tumor-specific therapy. BIOMATERIALS, 277 (121128). [PMID:34537502] [10.1016/j.biomaterials.2021.121128]
13. Cui Jing, Guo Yao, Wu Heshui, Xiong Jiongxin, Peng Tao. (2021) Everolimus regulates the activity of gemcitabine-resistant pancreatic cancer cells by targeting the Warburg effect via PI3K/AKT/mTOR signaling. MOLECULAR MEDICINE, 27 (1): (1-16). [PMID:33849427] [10.1186/s10020-021-00300-8]
14. Feng Fan, Lijun Jin, Lihua Yang. (2021) pH-Sensitive Nanoparticles Composed Solely of Membrane-Disruptive Macromolecules for Treating Pancreatic Cancer. ACS Applied Materials & Interfaces, 13 (11): (12824–12835). [PMID:33689289] [10.1021/acsami.0c16576]
15. Xin Zhang, Jiapeng Xu, Ronglin Yan, Yu Zhang, Zunqi Hu, Hongbing Fu, Qing You, Qingping Cai, Dejun Yang. (2020) FAM84B, amplified in pancreatic ductal adenocarcinoma, promotes tumorigenesis through the Wnt/β-catenin pathway. Aging-US, 12 (8): ( 6808–6822). [PMID:32291380] [10.18632/aging.103044]
16. Jing Dai, Yiqun Wang, Dinghao Wu, Fengju Wan, Yi Lu, Na Kong, Xiuchun Li, Jinkang Gong, Shengjie Ling, Yuan Yao. (2020) Biointerface mediates cytoskeletal rearrangement of pancreatic cancer cell and modulates its drug sensitivity. Colloid and Interface Science Communications, 35 (100250). [PMID:] [10.1016/j.colcom.2020.100250]
17. Yan Liang, Jing Zhang, Baocheng Tian, Zimei Wu, Darren Svirskis, Jingtian Han. (2020) A NAG-Guided Nano-Delivery System for Redox- and pH-Triggered Intracellularly Sequential Drug Release in Cancer Cells. International Journal of Nanomedicine, [PMID:32103941] [10.2147/IJN.S226249]
18. Lin Xiao-mian, Luo Wu, Wang Heng, Li Rong-zhen, Huang Yi-shan, Chen Lian-kuai, Wu Xiao-ping. (2019) The Role of Prostaglandin-Endoperoxide Synthase-2 in Chemoresistance of Non-Small Cell Lung Cancer. Frontiers in Pharmacology, 10 (836). [PMID:31440159] [10.3389/fphar.2019.00836]
19. Liu Yue, Lu Shan, Zhao Liang, Dong Xin, Zhu Zhenyu, Jin Yongsheng, Chen Haisheng, Lu Feng, Hong Zhanying, Chai Yifeng. (2018) Effects of glaucocalyxin A on human liver cancer cells as revealed by GC/MS- and LC/MS-based metabolic profiling. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410 (14): (3325-3335). [PMID:29651531] [10.1007/s00216-018-0996-8]
20. Tingyu Yu, Jiao Lin, Jin Zhao, Wei Huang, Lingwen Zeng, Zhiyuan Fang, Ning Xu. (2017) A simple in vitro tumor chemosensitivity assay based on cell penetrating peptide tagged luciferase. PLoS One, 12 (11): (e0186184). [PMID:29125836] [10.1371/journal.pone.0186184]
21. Peng-fei Liu, Yan-wei Cao, Shu-dong Zhang, Yang Zhao, Xiao-guang Liu, Hao-qing Shi, Ke-yao Hu, Guan-qun Zhu, Bo Ma, Hai-tao Niu. (2015) A bladder cancer microenvironment simulation system based on a microfluidic co-culture model. Oncotarget, 6 (35): ( 37695–37705). [PMID:26462177] [10.18632/oncotarget.6070]

References

1. Pourquier P, Gioffre C, Kohlhagen G, Urasaki Y, Goldwasser F, Hertel LW, Yu S, Pon RT, Gmeiner WH, Pommier Y. (2002) Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I.. Clin Cancer Res, 8 (8): (2499-504). [PMID:12171875] [10.1021/op500134e]
2. Dongchao Xu, Ajuan Liu, Qiang Liu, Hongchen Zhang, Mengyao Tian, Ying Bian, Xiaofeng Zhang, Meidan Ying, Hongzhang Shen. (2023) Cucurbitacin C suppresses the progression of pancreatic ductal adenocarcinoma via inhibition of the cGMP-PKG-VASP axis. BIOCHEMICAL PHARMACOLOGY, 217 (3): (115810). [PMID:37717690] [10.1016/j.bcp.2023.115810]
3. Yifan Luo, Chao Li, Yiwen Zhang, Peixin Liu, Hongyi Chen, Zhenhao Zhao, Yu Wang, Zheng Zhou, Haolin Song, Boyu Su, Chufeng Li, Xuwen Li, Tongyu Zhang, Haoyu You, Yuxing Wu, Zonghua Tian, Shilin Zhang, Yun Guo, Hongrui Fan, Qinjun Chen, Chen Jiang, Tao Sun. (2023) Gradient tumor microenvironment-promoted penetrating micelles for hypoxia relief and immunosuppression reversion in pancreatic cancer treatment. Acta Biomaterialia, [PMID:37276955] [10.1016/j.actbio.2023.05.047]
4. Nan Zhang, Junwei Zhang, Weiqi Cui, Deqiao Wu, Jingxian Zhang, Bo Wei, Lingbo Qu, Xia Xu. (2023) Artemisia argyi H.Lév. & Vaniot essential oil induces ferroptosis in pancreatic cancer cells via up-regulation of TFR1 and depletion of γ-glutamyl cycle. FITOTERAPIA, 168 (105522). [PMID:37169131] [10.1016/j.fitote.2023.105522]
5. Zhuo Yao, Qida Hu, Piaopiao Jin, Bowen Li, Yong Huang, Fu Zhang, Meng Wang, Junming Huang, Jing Huang, Shiyi Shao, Xinyu Zhao, Yuan Ping, Tingbo Liang. (2023) A Self-Assembly Combined Nano-Prodrug to Overcome Gemcitabine Chemo-Resistance of Pancreatic Tumors. ADVANCED FUNCTIONAL MATERIALS, (2214598). [PMID:] [10.1002/adfm.202214598]
6. Fu Zhang, Zhuo Yao, Piaopiao Jin, Mengqiu Xu, Qida Hu, Yuxuan Chen, Risheng Que, Tingbo Liang. (2023) A tumor microenvironment-stimuli responsive nano-prodrug for overcoming gemcitabine chemoresistance by co-delivered miRNA-21 modulator. Biomedical Materials, 18 (3): (35010). [PMID:36990101] [10.1088/1748-605X/acc8ac]
7. Fu Zhang, Qida Hu, Bowen Li, Yong Huang, Meng Wang, Shiyi Shao, Honglin Tang, Zhuo Yao, Yuan Ping, Tingbo Liang. (2023) A biomimetic nanodrug for enhanced chemotherapy of pancreatic tumors. JOURNAL OF CONTROLLED RELEASE, 354 (835). [PMID:36627026] [10.1016/j.jconrel.2023.01.007]
8. Hao Chi, Sheng Tian, Xiu Li, Yuchu Chen, Qiumin Xu, Qixiao Wang, Wenwan Shi, Michael Adu-Frimpong, Shanshan Tong. (2023) Construction of lipid raft-coupled agarose gels as bioaffinity chromatography materials and validation with tropomyosin-related kinase A-targeted drugs. JOURNAL OF CHROMATOGRAPHY A, 1691 (463803). [PMID:36731332] [10.1016/j.chroma.2023.463803]
9. Yaowei Guo, Jin Liu, Qinglin Tang, Cuicui Li, Yanying Zhang, Yao Wang, Yanxin Wang, Yupeng Bi, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore, Jianguo Tang. (2022) Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (12): (6597). [PMID:35743042] [10.3390/ijms23126597]
10. Yuting Zhu, Shanhao Han, Jianhui Li, Hongwei Gao, Bo Dong. (2022) Aqueous Extract of Sea Squirt (Halocynthia roretzi) with Potent Activity against Human Cancer Cells Acts Synergistically with Doxorubicin. Marine Drugs, 20 (5): (284). [PMID:35621935] [10.3390/md20050284]
11. Chen Ting-ting, Yuan Ming-ming, Tao Yu-mei, Ren Xiao-yan, Li Sufen. (2022) Engineering of Self-assembly Polymers Encapsulated with Dual Anticancer Drugs for the Treatment of Endometrial Cancer. JOURNAL OF CLUSTER SCIENCE, 33 (6): (2661-2671). [PMID:] [10.1007/s10876-021-02175-5]
12. Yingjie Kong, Yeneng Dai, Dashan Qi, Wenyu Du, Haiyang Ni, Fan Zhang, Honghai Zhao, Qingming Shen, Meixing Li, Quli Fan. (2021) Injectable and Thermosensitive Liposomal Hydrogels for NIR-II Light-Triggered Photothermal-Chemo Therapy of Pancreatic Cancer. ACS Applied Bio Materials, 4 (10): (7595–7604). [PMID:35006703] [10.1021/acsabm.1c00864]
13. Xiaoyu Xu, Zishan Zeng, Xin Ding, Ting Shan, Qiuxing Liu, Meixu Chen, Jie Chen, Meng Xia, Yuanfeng He, Zeqian Huang, Yanjuan Huang, Chunshun Zhao. (2021) Reactive oxygen species-activatable self-amplifying Watson-Crick base pairing-inspired supramolecular nanoprodrug for tumor-specific therapy. BIOMATERIALS, 277 (121128). [PMID:34537502] [10.1016/j.biomaterials.2021.121128]
14. Cui Jing, Guo Yao, Wu Heshui, Xiong Jiongxin, Peng Tao. (2021) Everolimus regulates the activity of gemcitabine-resistant pancreatic cancer cells by targeting the Warburg effect via PI3K/AKT/mTOR signaling. MOLECULAR MEDICINE, 27 (1): (1-16). [PMID:33849427] [10.1186/s10020-021-00300-8]
15. Feng Fan, Lijun Jin, Lihua Yang. (2021) pH-Sensitive Nanoparticles Composed Solely of Membrane-Disruptive Macromolecules for Treating Pancreatic Cancer. ACS Applied Materials & Interfaces, 13 (11): (12824–12835). [PMID:33689289] [10.1021/acsami.0c16576]
16. Xin Zhang, Jiapeng Xu, Ronglin Yan, Yu Zhang, Zunqi Hu, Hongbing Fu, Qing You, Qingping Cai, Dejun Yang. (2020) FAM84B, amplified in pancreatic ductal adenocarcinoma, promotes tumorigenesis through the Wnt/β-catenin pathway. Aging-US, 12 (8): ( 6808–6822). [PMID:32291380] [10.18632/aging.103044]
17. Jing Dai, Yiqun Wang, Dinghao Wu, Fengju Wan, Yi Lu, Na Kong, Xiuchun Li, Jinkang Gong, Shengjie Ling, Yuan Yao. (2020) Biointerface mediates cytoskeletal rearrangement of pancreatic cancer cell and modulates its drug sensitivity. Colloid and Interface Science Communications, 35 (100250). [PMID:] [10.1016/j.colcom.2020.100250]
18. Yan Liang, Jing Zhang, Baocheng Tian, Zimei Wu, Darren Svirskis, Jingtian Han. (2020) A NAG-Guided Nano-Delivery System for Redox- and pH-Triggered Intracellularly Sequential Drug Release in Cancer Cells. International Journal of Nanomedicine, [PMID:32103941] [10.2147/IJN.S226249]
19. Lin Xiao-mian, Luo Wu, Wang Heng, Li Rong-zhen, Huang Yi-shan, Chen Lian-kuai, Wu Xiao-ping. (2019) The Role of Prostaglandin-Endoperoxide Synthase-2 in Chemoresistance of Non-Small Cell Lung Cancer. Frontiers in Pharmacology, 10 (836). [PMID:31440159] [10.3389/fphar.2019.00836]
20. Liu Yue, Lu Shan, Zhao Liang, Dong Xin, Zhu Zhenyu, Jin Yongsheng, Chen Haisheng, Lu Feng, Hong Zhanying, Chai Yifeng. (2018) Effects of glaucocalyxin A on human liver cancer cells as revealed by GC/MS- and LC/MS-based metabolic profiling. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410 (14): (3325-3335). [PMID:29651531] [10.1007/s00216-018-0996-8]
21. Tingyu Yu, Jiao Lin, Jin Zhao, Wei Huang, Lingwen Zeng, Zhiyuan Fang, Ning Xu. (2017) A simple in vitro tumor chemosensitivity assay based on cell penetrating peptide tagged luciferase. PLoS One, 12 (11): (e0186184). [PMID:29125836] [10.1371/journal.pone.0186184]
22. Peng-fei Liu, Yan-wei Cao, Shu-dong Zhang, Yang Zhao, Xiao-guang Liu, Hao-qing Shi, Ke-yao Hu, Guan-qun Zhu, Bo Ma, Hai-tao Niu. (2015) A bladder cancer microenvironment simulation system based on a microfluidic co-culture model. Oncotarget, 6 (35): ( 37695–37705). [PMID:26462177] [10.18632/oncotarget.6070]

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