NBI 31772 - ≥98%(HPLC) , CAS No.374620-70-9

CAS: 374620-70-9 Cat. No.: N287388 Molecular Weight: 341.27
AVAILABLE TO ORDER
GRADE & PURITY ≥98%(HPLC)
Synonyms
BDBM50106431 | DTXSID80741040 | UNII-7DYH3XNP6H | 1-[(3,4-Dioxocyclohexa-1,5-dien-1-yl)(hydroxy)methylidene]-6,7-dihydroxy-1,2-dihydroisoquinoline-3-carboxylic acid | 7DYH3XNP6H | AKOS025147334 | ZPA62070 | 6,7-dihydroxy-1-(3,4-dihydroxybenzoyl)isoquinoli
Storage
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
1mg
N287388-1mg
3
$79.90
5mg
N287388-5mg
3
$239.90
10mg
N287388-10mg
2
$379.90
25mg
N287388-25mg
2
$659.90
50mg
N287388-50mg
1
$959.90
Enter a quantity for the sizes you want to add.
🧪

Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
BDBM50106431 | DTXSID80741040 | UNII-7DYH3XNP6H | 1-[(3, 4-Dioxocyclohexa-1, 5-dien-1-yl)(hydroxy)methylidene]-6, 7-dihydroxy-1, 2-dihydroisoquinoline-3-carboxylic acid | 7DYH3XNP6H | AKOS025147334 | ZPA62070 | 6, 7-dihydroxy-1-(3, 4-dihydroxybenzoyl)isoquinoli
Specifications & Purity
≥98%(HPLC)
Biochemical and Physiological Mechanisms
High affinity insulin-like growth factor-1 binding protein (IGFBP) inhibitor (Kivalues are 1 - 24 nM for all six human subtypes). Displaces insulin-like growth factor-1 (IGF-1) from the IGF-1:IGFBP complex and suppresses IGF1-induced proliferation of 3T3
Storage
Store at -20°C, Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥98%(HPLC)
Names and Identifiers
Canonical SmilesC1=CC(=C(C=C1C(=O)C2=NC(=CC3=CC(=C(C=C32)O)O)C(=O)O)O)O
IUPAC Name1-(3,4-dihydroxybenzoyl)-6,7-dihydroxyisoquinoline-3-carboxylic acid
InChIKeyZCMFEWUYBFMLIN-UHFFFAOYSA-N
INCHI1S/C17H11NO7/c19-11-2-1-7(4-12(11)20)16(23)15-9-6-14(22)13(21)5-8(9)3-10(18-15)17(24)25/h1-6,19-22H,(H,24,25)
Isomeric SMILES C1=CC(=C(C=C1C(=O)C2=NC(=CC3=CC(=C(C=C32)O)O)C(=O)O)O)O
Molecular Weight 341.27
Reaxy-Rn 9087936
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9087936&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Associated Targets(Human)
IGFBP1 Tchem Insulin-like growth factor-binding protein 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
IGFBP2 Tchem Insulin-like growth factor-binding protein 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
IGFBP3 Tchem Insulin-like growth factor-binding protein 3 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
IGFBP4 Tchem Insulin-like growth factor-binding protein 4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
IGFBP5 Tchem Insulin-like growth factor-binding protein 5 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
IGFBP6 Tchem Insulin-like growth factor-binding protein 6 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
IGFBP6 Tchem Insulin-like growth factor binding protein 6 (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IGFBP1 Tchem Insulin-like growth factor binding protein 1 (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IGFBP3 Tchem Insulin-like growth factor binding protein 3 (46 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IGFBP4 Tchem Insulin-like growth factor binding protein 4 (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IGFBP5 Tchem Insulin-like growth factor binding protein 5 (37 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IGFBP2 Tchem Insulin-like growth factor binding protein 2 (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeDateItem
A2426311Certificate of AnalysisDec 25, 2023 N287388
A2426312Certificate of AnalysisDec 25, 2023 N287388
A2426313Certificate of AnalysisDec 25, 2023 N287388
A2426314Certificate of AnalysisDec 25, 2023 N287388
A2426315Certificate of AnalysisDec 25, 2023 N287388
A2426316Certificate of AnalysisDec 25, 2023 N287388
A2426318Certificate of AnalysisDec 25, 2023 N287388
Chemical and Physical Properties
SolubilitySolvent:DMSO, Max Conc. mg/mL: 34.13, Max Conc. mM: 100
Molecular Weight341.270 g/mol
XLogP32.200
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass341.054 Da
Monoisotopic Mass341.054 Da
Topological Polar Surface Area148.000 Ų
Heavy Atom Count25
Formal Charge0
Complexity527.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Solution Calculators
Reviews

Customer Reviews

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