TC-DAPK 6 - ≥98% , CAS No.315694-89-4

CAS: 315694-89-4 Cat. No.: T646454 Molecular Weight: 276.29 PubChem CID: 5676111

GRADE & PURITY ≥98%

Synonyms

EX-A2167 | Z56820688 | EN300-260619 | AC-35960 | EN300-7536106 | 2-(2-phenylethenyl)-4-[(pyridin-3-yl)methylidene]-4,5-dihydro-1,3-oxazol-5-one | TC-DAPK-6 | (E)-4-(pyridin-3-ylmethylene)-2-((E)-styryl)oxazol-5(4H)-one | HY-15513 | 4-(pyridin-3-ylmethylen

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor ( IC 50 =69 and 225 nM against DAPK1 and DAPK3 , respectively, with 10 μM ATP).

In Vitro

TC-DAPK 6 is found to be the most potent Death-associated protein kinase (DAPK) inhibitor with enzyme selectivity. When assayed with 10 μM ATP, the IC 50 values for DAPK1 and DAPK3 are 69 and 225 nM, respectively. TC-DAPK 6 also inhibits p70S6K (1 μM < IC 50 < 10 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 69 nM (DAPK1), 225 nM (DAPK3)

Specifications

Synonyms

EX-A2167 | Z56820688 | EN300-260619 | AC-35960 | EN300-7536106 | 2-(2-phenylethenyl)-4-[(pyridin-3-yl)methylidene]-4, 5-dihydro-1, 3-oxazol-5-one | TC-DAPK-6 | (E)-4-(pyridin-3-ylmethylene)-2-((E)-styryl)oxazol-5(4H)-one | HY-15513 | 4-(pyridin-3-ylmethylen

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor ( IC 50 =69 and 225 nM against DAPK1 and DAPK3 , respectively, with 10 μM ATP).

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: C1=CC=C(C=C1)C=CC2=NC(=CC3=CN=CC=C3)C(=O)O2
• IUPAC Name: (4E)-2-[(E)-2-phenylethenyl]-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one
• InChIKey: GFGMISOSPOPSHN-QCTDOKRBSA-N
• INCHI: 1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H/b9-8+,15-11+
• Isomeric SMILES: C1=CC=C(C=C1)/C=C/C2=N/C(=C/C3=CN=CC=C3)/C(=O)O2
• PubChem CID: 5676111
• Molecular Weight: 276.29

Chemical and Physical Properties

• Solubility: DMSO : 18.67 mg/mL (67.57 mM; Need ultrasonic and warming)
• Molecular Weight: 276.290 g/mol
• XLogP3: 2.900
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 276.09 Da
• Monoisotopic Mass: 276.09 Da
• Topological Polar Surface Area: 51.600 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 473.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 1