MK-0941 - ≥99% , Hexokinase type IV activator, CAS No.1137916-97-2, Hexokinase type IV activator

CAS: 1137916-97-2 Cat. No.: M647206 Molecular Weight: 556.61 PubChem CID: 25235800

GRADE & PURITY ≥99%

Synonyms

EX-A1851 | BCP25241 | MK 0941 | AKOS040733749 | 3-((6-(ethylsulfonyl)-3-pyridinyl)oxy)-5-((1S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide | 3-(6-ethylsulfonylpyridin-3-yl)oxy-5-[(2S)-1-hydroxypropan-2-yl]oxy-N-(1-methylpyrazol-3-yl)be

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

MK-0941 is a potent, orally active and allosteric glucokinase activator, with EC 50 s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 has potential in the treatment of type 2 diabetes

Form:Solid

IC50& Target:EC50: 240 nM (Recombinant human glucokinase, 2.5 mM glucose), 65 nM (Recombinant human glucokinase, 10 mM glucose)

Specifications

Synonyms

EX-A1851 | BCP25241 | MK 0941 | AKOS040733749 | 3-((6-(ethylsulfonyl)-3-pyridinyl)oxy)-5-((1S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide | 3-(6-ethylsulfonylpyridin-3-yl)oxy-5-[(2S)-1-hydroxypropan-2-yl]oxy-N-(1-methylpyrazol-3-yl)be

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

MK-0941 is a potent, orally active and allosteric glucokinase activator, with EC 50 s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 has potential in the treatment of type 2 diabetes

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ACTIVATOR

Mechanism of action

Hexokinase type IV activator

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CCS(=O)(=O)C1=NC=C(C=C1)OC2=CC(=CC(=C2)C(=O)NC3=NN(C=C3)C)OC(C)CO.CS(=O)(=O)O
• IUPAC Name: 3-(6-ethylsulfonylpyridin-3-yl)oxy-5-[(2S)-1-hydroxypropan-2-yl]oxy-N-(1-methylpyrazol-3-yl)benzamide;methanesulfonic acid
• InChIKey: PIDNRTWDGDJKSQ-UQKRIMTDSA-N
• INCHI: 1S/C21H24N4O6S.CH4O3S/c1-4-32(28,29)20-6-5-16(12-22-20)31-18-10-15(9-17(11-18)30-14(2)13-26)21(27)23-19-7-8-25(3)24-19;1-5(2,3)4/h5-12,14,26H,4,13H2,1-3H3,(H,23,24,27);1H3,(H,2,3,4)/t14-;/m0./s1
• Isomeric SMILES: CCS(=O)(=O)C1=NC=C(C=C1)OC2=CC(=CC(=C2)C(=O)NC3=NN(C=C3)C)O[C@@H](C)CO.CS(=O)(=O)O
• Alternate CAS: 1137916-97-2
• PubChem CID: 25235800
• MeSH Entry Terms: 3-((6-(ethylsulfonyl)-3-pyridinyl)oxy)-5-(2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide;MK 0941;MK-0941;MK0941
• Molecular Weight: 556.61

Chemical and Physical Properties

• Solubility: DMSO : 260 mg/mL (467.11 mM; Need ultrasonic)
• Sensitivity: Moisture sensitive.
• Molecular Weight: 556.600 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 9
• Exact Mass: 556.13 Da
• Monoisotopic Mass: 556.13 Da
• Topological Polar Surface Area: 204.000 Ų
• Heavy Atom Count: 37
• Formal Charge: 0
• Complexity: 810.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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