≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
DMX-5084 DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.
Targets
human MAP4K4 (Cell-free assay); human MAP4K4 (Cell-free assay); MINK1/MAP4K6 (Cell-free assay); TNIK/MAP4K7 (Cell-free assay) 8.55(pIC50) ;3 nM; 8.18(pIC50); 7.96(pIC50)
| ALogP | 3.122 |
|---|---|
| hba_count | 4 |
| HBD Count | 1 |
| Rotatable Bond | 6 |
| Pubchem Sid | 504773495 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773495 |
| Canonical Smiles | COCCOC1=CC=C(C=C1)C2=CN(C3=C2C(=O)NC=N3)C4=CC=CC=C4 |
| IUPAC Name | 5-[4-(2-methoxyethoxy)phenyl]-7-phenyl-3H-pyrrolo[2,3-d]pyrimidin-4-one |
| InChIKey | FUSHFOGORKZNNQ-UHFFFAOYSA-N |
| INCHI | 1S/C21H19N3O3/c1-26-11-12-27-17-9-7-15(8-10-17)18-13-24(16-5-3-2-4-6-16)20-19(18)21(25)23-14-22-20/h2-10,13-14H,11-12H2,1H3,(H,22,23,25) |
| Molecular Weight | 361.39 |
| Reaxy-Rn | 34268902 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=34268902&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 H2206505 | Certificate of Analysis | May 12, 2025 | D412287 |
| H2206562 | Certificate of Analysis | May 12, 2025 | D412287 |
| H2206563 | Certificate of Analysis | May 12, 2025 | D412287 |
| H2206564 | Certificate of Analysis | May 12, 2025 | D412287 |
| Solubility | Solubility (25°C) In vitro DMSO: 72 mg/mL (199.23 mM); Ethanol: 1.5 mg/mL (4.15 mM); Water: Insoluble; |
|---|---|
| DMSO(mg / mL) Max Solubility | 72 |
| DMSO(mM) Max Solubility | 199.230747945433 |
| Water(mg / mL) Max Solubility | ＜1 |
| Molecular Weight | 361.400 g/mol |
| XLogP3 | 2.900 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 6 |
| Exact Mass | 361.143 Da |
| Monoisotopic Mass | 361.143 Da |
| Topological Polar Surface Area | 64.900 Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 527.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
