Demethyleneberberine - 2mM in DMSO , CAS No.25459-91-0

CAS: 25459-91-0 Cat. No.: D422882 Molecular Weight: 324.35

GRADE & PURITY 2mM in DMSO

Synonyms

Dehydrostepholidine chloride | HY-N0592 | BDBM50300549 | AKOS037514619 | s3299 | AC-34618 | 9,10-Dimethoxy-5,6-dihydro-7lambda~5~-isoquino[3,2-a]isoquinoline-2,3-diol hydrochloride | 9,10-dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishesmyeloperoxidase (MPO)activity, while significantly reduces the production of pro-inflammatory cytokines, such asinterleukin (IL)-6andtumor necrosis factor-α (TNF-α), and inhibits the activation ofNF-κBsignaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating

Targets

NF-κB ; MPO ; IL-6 ; TNF-α ; IL-1β 33791,

Specifications

Synonyms

Dehydrostepholidine chloride | HY-N0592 | BDBM50300549 | AKOS037514619 | s3299 | AC-34618 | 9, 10-Dimethoxy-5, 6-dihydro-7lambda~5~-isoquino[3, 2-a]isoquinoline-2, 3-diol hydrochloride | 9, 10-dimethoxy-5, 6-dihydroisoquinolino[2, 1-b]isoquinolin-7-ium-2, 3-diol

Specifications & Purity

2mM in DMSO

Biochemical and Physiological Mechanisms

Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as inter

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)O)OC
• IUPAC Name: 9,10-dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol
• InChIKey: HVTCKKMWZDDWOY-UHFFFAOYSA-O
• INCHI: 1S/C19H17NO4/c1-23-18-4-3-11-7-15-13-9-17(22)16(21)8-12(13)5-6-20(15)10-14(11)19(18)24-2/h3-4,7-10,22H,5-6H2,1-2H3/p+1
• Isomeric SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)O)OC
• Molecular Weight: 324.35
• Reaxy-Rn: 1554250
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1554250&ln=

Chemical and Physical Properties

• Molecular Weight: 324.300 g/mol
• XLogP3: 3.100
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 324.124 Da
• Monoisotopic Mass: 324.124 Da
• Topological Polar Surface Area: 62.800 Ų
• Heavy Atom Count: 24
• Formal Charge: 1
• Complexity: 447.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1