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· · COA & SDS available for every product · Same-day shipping on in-stock items RMM 46 - ≥98%(HPLC) , CAS No.1307896-46-3
Synonyms
2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide
Shipped In
Ice chest + Ice pads
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Why this grade ≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
2-Cyano-N-(2-hydroxy-1, 1-dimethylethyl)-3-[3-(3, 4, 5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide
Specifications & Purity
≥98%(HPLC)
Biochemical and Physiological Mechanisms
MSK/RSK family kinase inhibitor. Exhibits selectivity for RSK2 over NEK2 and PLK1 (IC50s are 12, 530 and 2200 nM, respectively). Inhibits MSK1, MSK2, RSK2 and RSK3 in cellular assays. Reduces CREB phosphorylation in HeLa cells.
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers Canonical Smiles CC(C)(CO)NC(=O)C(=CC1=CC2=C(C=C1)NN=C2C3=CC(=C(C(=C3)OC)OC)OC)C#N IUPAC Name (E)-2-cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]prop-2-enamide InChIKey FCCMYBKAZCDQGX-LZYBPNLTSA-N INCHI 1S/C24H26N4O5/c1-24(2,13-29)26-23(30)16(12-25)8-14-6-7-18-17(9-14)21(28-27-18)15-10-19(31-3)22(33-5)20(11-15)32-4/h6-11,29H,13H2,1-5H3,(H,26,30)(H,27,28)/b16-8+ Isomeric SMILES CC(C)(CO)NC(=O)/C(=C/C1=CC2=C(C=C1)NN=C2C3=CC(=C(C(=C3)OC)OC)OC)/C#N PubChem CID 67206797 Molecular Weight 450.5
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 45.05, Max Conc. mM: 100 Molecular Weight 450.500 g/mol XLogP3 2.700 Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7 Rotatable Bond Count 8 Exact Mass 450.19 Da Monoisotopic Mass 450.19 Da Topological Polar Surface Area 129.000 Ų Heavy Atom Count 33 Formal Charge 0 Complexity 749.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 1 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 1 Covalently-Bonded Unit Count 1
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