OSI-027 - ≥95% , Serine/threonine-protein kinase mTOR inhibitor, CAS No.936890-98-1, Serine/threonine-protein kinase mTOR inhibitor

CAS: 936890-98-1 Cat. No.: O127920 Molecular Weight: 406.45

GRADE & PURITY ≥95%

Synonyms

4-[4-amino-5-(7-methoxy-2-indolylidene)-1H-imidazo[5,1-f][1,2,4]triazin-7-yl]-1-cyclohexanecarboxylic acid | AC-4802 | DB12387 | OSI 027 | (1r,4r)-4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexane-1-carboxylic acid | CCG-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

4-[4-amino-5-(7-methoxy-2-indolylidene)-1H-imidazo[5, 1-f][1, 2, 4]triazin-7-yl]-1-cyclohexanecarboxylic acid | AC-4802 | DB12387 | OSI 027 | (1r, 4r)-4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5, 1-f][1, 2, 4]triazin-7-yl)cyclohexane-1-carboxylic acid | CCG-

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

OSI-027 is a potent mammalian target of rapamycin (mTOR) kinase inhibitor.Potent, ATP-competitive mTOR kinase inhibitor. Inhibits TORC1 (IC 50 = 22 nM) and TORC2 (IC 50 = 65 nM) mTor complexes. Greater than 100-fold selective for mTOR versus PI3K-alpha, P

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Serine/threonine-protein kinase mTOR inhibitor

Note

Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥95%

Product Properties

• ALogP: 2

Names and Identifiers

• Pubchem Sid: 504773227
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773227
• Canonical Smiles: COC1=CC=CC2=C1NC(=C2)C3=C4C(=NC=NN4C(=N3)C5CCC(CC5)C(=O)O)N
• IUPAC Name: 4-[4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexane-1-carboxylic acid
• InChIKey: JROFGZPOBKIAEW-UHFFFAOYSA-N
• INCHI: 1S/C21H22N6O3/c1-30-15-4-2-3-13-9-14(25-16(13)15)17-18-19(22)23-10-24-27(18)20(26-17)11-5-7-12(8-6-11)21(28)29/h2-4,9-12,25H,5-8H2,1H3,(H,28,29)(H2,22,23,24)
• Isomeric SMILES: COC1=CC=CC2=C1NC(=C2)C3=C4C(=NC=NN4C(=N3)C5CCC(CC5)C(=O)O)N
• Molecular Weight: 406.45
• Reaxy-Rn: 25803339
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25803339&ln=

Chemical and Physical Properties

• Solubility: DMSO 18 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
• Molecular Weight: 406.400 g/mol
• XLogP3: 2.000
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 406.175 Da
• Monoisotopic Mass: 406.175 Da
• Topological Polar Surface Area: 131.000 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 630.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1