≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
BL-918 BL-918 is a potent, orally active activator of UNC-51-like kinase 1 (ULK1) with EC50 of 24.14 nM and Kd of 0.719 μM. BL-918 induces cytoprotective autophagy for Parkinson's disease treatment.
Targets
ULK1 (Cell-free assay); ULK1 (Cell-free assay) 24.14 nM(EC50); 0.719 μM(Kd)
| Pubchem Sid | 504773611 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773611 |
| Canonical Smiles | C1=CC=C(C=C1)C(C(=O)NC2=C(C=C(C=C2)F)F)NC(=S)NC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F |
| IUPAC Name | (2R)-2-[[3,5-bis(trifluoromethyl)phenyl]carbamothioylamino]-N-(2,4-difluorophenyl)-2-phenylacetamide |
| InChIKey | BDBWQANRZRCMMD-LJQANCHMSA-N |
| INCHI | 1S/C23H15F8N3OS/c24-15-6-7-18(17(25)11-15)33-20(35)19(12-4-2-1-3-5-12)34-21(36)32-16-9-13(22(26,27)28)8-14(10-16)23(29,30)31/h1-11,19H,(H,33,35)(H2,32,34,36)/t19-/m1/s1 |
| Isomeric SMILES | C1=CC=C(C=C1)[C@H](C(=O)NC2=C(C=C(C=C2)F)F)NC(=S)NC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F |
| Molecular Weight | 533.44 |
| Reaxy-Rn | 56497606 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=56497606&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 H2206135 | Certificate of Analysis | May 12, 2025 | B412568 |
| H2206136 | Certificate of Analysis | May 12, 2025 | B412568 |
| H2206137 | Certificate of Analysis | May 12, 2025 | B412568 |
| H2206138 | Certificate of Analysis | May 12, 2025 | B412568 |
| Solubility | Solubility (25°C) In vitro DMSO: 100 mg/mL (187.46 mM); Ethanol: 100 mg/mL (187.46 mM); Water: Insoluble; |
|---|---|
| Molecular Weight | 533.400 g/mol |
| XLogP3 | 6.100 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 5 |
| Exact Mass | 533.081 Da |
| Monoisotopic Mass | 533.081 Da |
| Topological Polar Surface Area | 85.300 Ų |
| Heavy Atom Count | 36 |
| Formal Charge | 0 |
| Complexity | 737.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Lin Liu, Zhuangzhuang Chu, Xiao Han, Jin Wu, Kunzhan Cai, Jiaohong Wang, Zixiang Guo, Shan Gao, Guoqing Li, Chunbo Tang. (2025) Creatine promotes osteogenic differentiation of dental pulp stem cells via the AMPK-ULK1-autophagy axis. CONNECTIVE TISSUE RESEARCH, [PMID:39930963] [10.1080/03008207.2025.2459243] |
