Dyngo-4a - 10mM in DMSO , CAS No.1256493-34-1

CAS: 1256493-34-1 Cat. No.: D421075 Molecular Weight: 338.31 EC Number: 802-865-7

GRADE & PURITY 10mM in DMSO

Synonyms

Hydroxy Dynasore | 3-hydroxy-N-[(E)-(2,4,5-trihydroxyphenyl)methylideneamino]naphthalene-2-carboxamide | HY-13863 | 2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide | EX-A4203 | 2-Naphthalenecarboxylic acid,3-hydrox

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

product description：

Hydroxy Dynasore (Dyngo-4a), a structural analog of Dynasore (HY-15304), is an potency improved, low cytotoxicity and non‐specific binding dynamin inhibitor with IC50 values of 0.38 μM and 2.3 μM for brain dynamin I and recombinant rat dynamin II, respectively. Hydroxy Dynasore inhibits dynamin‐dependent endocytosis of transferrin with an IC50 of 5.7 μM in vitro.

Specifications

Synonyms

Hydroxy Dynasore | 3-hydroxy-N-[(E)-(2, 4, 5-trihydroxyphenyl)methylideneamino]naphthalene-2-carboxamide | HY-13863 | 2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2, 4, 5-trihydroxyphenyl)Methylene]hydrazide | EX-A4203 | 2-Naphthalenecarboxylic acid, 3-hydrox

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Novel, highly potent dynamin inhibitor (IC 50 values are 400 nM and 200 nM at dynamin I and II human-recombinant, respectively). Inhibits clathrin-mediated endocytosis (IC 50 = 5.5 µM). Dynasore analog.

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Canonical Smiles: C1=CC=C2C=C(C(=CC2=C1)C(=O)NN=CC3=CC(=C(C=C3O)O)O)O
• IUPAC Name: 3-hydroxy-N-[(E)-(2,4,5-trihydroxyphenyl)methylideneamino]naphthalene-2-carboxamide
• InChIKey: UAXHPUSKEWEOAP-DJKKODMXSA-N
• INCHI: 1S/C18H14N2O5/c21-14-8-17(24)16(23)7-12(14)9-19-20-18(25)13-5-10-3-1-2-4-11(10)6-15(13)22/h1-9,21-24H,(H,20,25)/b19-9+
• Isomeric SMILES: C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3O)O)O)O
• Molecular Weight: 338.31
• Reaxy-Rn: 26852351
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26852351&ln=

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Light sensitive
• Molecular Weight: 338.300 g/mol
• XLogP3: 3.200
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 338.09 Da
• Monoisotopic Mass: 338.09 Da
• Topological Polar Surface Area: 122.000 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 500.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

References

1. Ning Sun, Bingyan Shen, Sijun Zhao, Yalin Song, Caili Zhang, Xianghua Liu, Zhen-qiang Zhang, Haigang Wu, Qiuling Ma.  (2025)  Disease-state protein coronas reprogram 70-nm gold nanoparticle uptake via complement–apolipoprotein opsonization in glioblastoma cohorts.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.171110]

2. Xiaofei Xin, Yifu Lyu, Huanyu Qin, Jinyu Dai, Di Wu, Yu Ding, Qiang Tian, Chao Qin, Na Li, Lifang Yin.  (2026)  Structure–Activity-Driven Multicompartment Lipid Nanoparticles for Synergistic mRNA and siRNA Codelivery in Acute Myeloid Leukemia.  Journal of the American Chemical Society,      [PMID:41719142] [10.1021/jacs.5c23209]