(±)-Sulfinpyrazone - Moligand™, ≥96% , Antagonist of FPR1;Inhibitor of Urate anion exchanger 1, CAS No.57-96-5, Antagonist of FPR1;Inhibitor of Urate anion exchanger 1

CAS: 57-96-5 Cat. No.: X139028 Molecular Weight: 404.48 EC Number: 200-357-4 PubChem CID: 5342

GRADE & PURITY Moligand™, ≥96%

Synonyms

4-(2-Benzenesulfinylethyl)-1,2-diphenylpyrazolidine-3,5-dione | Anturidin | DTXCID003618 | M04AB02 | sulfinpyrazone (SPZ) | Sulfinpyrazone [USP:INN:BAN:JAN] | HMS3712J22 | Prestwick_455 | Sulfinpyrazone (JAN/USP/INN) | SULFINPYRAZONE [INN] | Spectrum5_000

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Product Describtion:

Sulfinpyrazone is a free radical scavenger that is an inhibitor of organic anion transporters (OATP) and is an effective uricosuric chemical. It is a proposed nonselective UGT (UDP-glucuronosyltransferases) inhibitor. The transport of sulfinpyrazone in MDCKII-MRP1 cells is associated with GSH export, except in high concentrations, and is a substrate for MRP2 (multidrug resistance protein).

Product Application：

cleaning products，cosmetics，food and beverages，forensics and toxicology，personal care，pharmaceutical (small molecule)，veterinary

Specifications

Synonyms

4-(2-Benzenesulfinylethyl)-1, 2-diphenylpyrazolidine-3, 5-dione | Anturidin | DTXCID003618 | M04AB02 | sulfinpyrazone (SPZ) | Sulfinpyrazone [USP:INN:BAN:JAN] | HMS3712J22 | Prestwick_455 | Sulfinpyrazone (JAN/USP/INN) | SULFINPYRAZONE [INN] | Spectrum5_000

Specifications & Purity

Moligand™, ≥96%

Biochemical and Physiological Mechanisms

Sulfamethoxazole, one of the most studied inhibitors of Platelet Cox, is an acid excretory agent that reabsorbs Competitive inhibition acid in the proximal tubules of the kidney.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ANTAGONIST, INHIBITOR

Mechanism of action

Antagonist of FPR1;Inhibitor of Urate anion exchanger 1

Note

Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥96%

Names and Identifiers

• Pubchem Sid: 504750874
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504750874
• Canonical Smiles: C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCS(=O)C4=CC=CC=C4
• IUPAC Name: 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione
• InChIKey: MBGGBVCUIVRRBF-UHFFFAOYSA-N
• INCHI: 1S/C23H20N2O3S/c26-22-21(16-17-29(28)20-14-8-3-9-15-20)23(27)25(19-12-6-2-7-13-19)24(22)18-10-4-1-5-11-18/h1-15,21H,16-17H2
• Isomeric SMILES: C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCS(=O)C4=CC=CC=C4
• WGK Germany: 3
• RTECS: UQ8575000
• PubChem CID: 5342
• Molecular Weight: 404.48

Associated Targets(Human)

SLC22A12 Tclin Solute carrier family 22 member 12 (1 Activities)

Discover Target: SLC22A12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FPR1 Tchem fMet-Leu-Phe receptor (1 Activities)

Discover Target: FPR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NAPRT Tchem Nicotinate phosphoribosyltransferase (0 Activities)

Discover Target: NAPRT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Slightly soluble in water; Soluble in Acetone,Chloroform; Slightly soluble in Alcohol,Ether
• Melt Point(°C): 131 °C
• Molecular Weight: 404.500 g/mol
• XLogP3: 2.300
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 404.119 Da
• Monoisotopic Mass: 404.119 Da
• Topological Polar Surface Area: 76.900 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 571.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Jingxuan Qiu, Xinzhu Zhao, Gang Liu, Chaoqun Zhang, Libo Wang, Yeming Wang, Shizhe Li, Lei Wang, Cen Yao, Liping Zhao, Peng Wang, Jia Zhang, Jing Lin, Rui Zhang, Yunchun Guo, Huiliang Wang.  (2023)  Solubility Behavior and Data Correlation of Sulfinpyrazone in Thirteen Pure Solvents from 283.15 to 323.15 K.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.3c00463]

2. Chen Sun, Mingyu Zhang, Yanhong Zhao, Jianxin Pang, Ying Peng, Jiang Zheng.  (2020)  An LC-MS/MS- and hURAT1 cell-based approach for screening of uricosuric agents.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:32905987] [10.1016/j.jchromb.2020.122336]

3. Chen Chen, Peng Shi, Haihua Wu, Tingting Zhang, Min Zhang, Xueyao Zhang.  (2026)  The transcription factor CncC/Maf modulates imidacloprid susceptibility by regulating UGT392C1 in Locusta migratoria.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:41831881] [10.1016/j.pestbp.2026.107013]