Sivelestat sodium salt - ≥98%(HPLC) , CAS No.150374-95-1

CAS: 150374-95-1 Cat. No.: S287743 Molecular Weight: 456.44 PubChem CID: 23664980

GRADE & PURITY ≥98%(HPLC)

Synonyms

Sivelestat (sodium) | HY-17443A | NCGC00261500-01 | SIVELESTAT SODIUM SALT ANHYDROUS [MI] | sodium;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate | A14073 | Q27236615 | CCG-222119 | J-008691 | Sivelestat sodium anhydrous |

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

Sivelestat (sodium) | HY-17443A | NCGC00261500-01 | SIVELESTAT SODIUM SALT ANHYDROUS [MI] | sodium;2-[[2-[[4-(2, 2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate | A14073 | Q27236615 | CCG-222119 | J-008691 | Sivelestat sodium anhydrous |

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Selective leukocyte elastase inhibitor (IC50= 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil transmigrationin vitro. Significantly attenuates ischemia-induced spinal cord injury, decre

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 504769500
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504769500
• Canonical Smiles: CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].[Na+]
• IUPAC Name: sodium;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate
• InChIKey: ZAIFANJZUGNYCK-UHFFFAOYSA-M
• INCHI: 1S/C20H22N2O7S.Na/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24;/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24);/q;+1/p-1
• Isomeric SMILES: CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].[Na+]
• PubChem CID: 23664980
• Molecular Weight: 456.44

Associated Targets(Human)

ELANE Tclin Neutrophil elastase (3 Activities)

Discover Target: ELANE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ELANE Tclin Leukocyte elastase (8173 Activities)

Discover Target: ELANE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 22.82, Max Conc. mM: 50
• Molecular Weight: 456.400 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 9
• Exact Mass: 456.097 Da
• Monoisotopic Mass: 456.097 Da
• Topological Polar Surface Area: 150.000 Ų
• Heavy Atom Count: 31
• Formal Charge: 0
• Complexity: 738.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Hao-Dong Yang, Zhi-Shu Tang, Tao-Tao Xue, Huai-Li Xu, Bao-Long Hou, Ya-Ya Zhu, Zeng-Hu Su, Hong-Bo Xu.  (2023)  Monoterpenoids from the root bark of Acanthopanax gracilistylus and their inhibitory effects on neutrophil elastase, 5-lipoxygenase, andcyclooxygenase-2 in vitro.  PHYTOCHEMISTRY,      [PMID:37683990] [10.1016/j.phytochem.2023.113851]

2. Hao-Dong Yang, Yuan-Gui Yang, Zhi-Shu Tang, Kang Ma, Hong-Bo Xu.  (2024)  Identification of lignans as selective cyclooxygenase-2 inhibitors from the extract of Acanthopanacis cortex.  PHYTOCHEMISTRY,      [PMID:38972441] [10.1016/j.phytochem.2024.114208]