≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
ADAMTS-5 Inhibitor is a thioxothiazolidinone compound that possesses a Zn|2+|-chelating structural motif and acts as an ADAMTS-5 (aggrecanase-2) inhibitor (IC|50|= 1.1 μM) with ~40-fold selectivity over ADAMTS-4 (aggrecanase-1).
| pKa | pKa: 6.69 (Predicted) |
|---|
| Pubchem Sid | 504768477 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504768477 |
| Canonical Smiles | CN1C(=C(C(=N1)C(F)(F)F)C=C2C(=O)NC(=S)S2)SCC3=CC=C(C=C3)Cl |
| IUPAC Name | (5Z)-5-[[5-[(4-chlorophenyl)methylsulfanyl]-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one |
| InChIKey | CVYPRDPBCXSVBN-WDZFZDKYSA-N |
| INCHI | 1S/C16H11ClF3N3OS3/c1-23-14(26-7-8-2-4-9(17)5-3-8)10(12(22-23)16(18,19)20)6-11-13(24)21-15(25)27-11/h2-6H,7H2,1H3,(H,21,24,25)/b11-6- |
| Isomeric SMILES | CN1C(=C(C(=N1)C(F)(F)F)/C=C\2/C(=O)NC(=S)S2)SCC3=CC=C(C=C3)Cl |
| Molecular Weight | 449.92 |
| Reaxy-Rn | 10717190 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10717190&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 K2215224 | Certificate of Analysis | Aug 13, 2025 | A334806 |
| K2215225 | Certificate of Analysis | Aug 13, 2025 | A334806 |
| K2215409 | Certificate of Analysis | Aug 13, 2025 | A334806 |
| K2215410 | Certificate of Analysis | Aug 13, 2025 | A334806 |
| Solubility | Soluble in DMSO (10 mg/ml). |
|---|---|
| Molecular Weight | 449.900 g/mol |
| XLogP3 | 5.000 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 4 |
| Exact Mass | 448.97 Da |
| Monoisotopic Mass | 448.97 Da |
| Topological Polar Surface Area | 130.000 Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 626.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 1 |
| Covalently-Bonded Unit Count | 1 |
