An organo-selenium compound possessing antioxidant properties. Inhibits mammalian lipoxygenases in the absence of thiol groups, and glutathione S-transferase and papain via the interaction with cysteine residues. Also inhibits indoleamine 2,3-dioxygenase
Storage Temp
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Mechanism of action
Antioxidant
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Ebselen is an interesting organoselenium compound displaying antiinflammatory and antioxidant properties. Ebselen is shown to inhibit the 5-lipoxygenase (5-LO) and 15-lipoxygenase (15-LO) enzymes in the absence of glutathione. Ebselen also inhibits Cox (cyclooxygenase), PKC (protein kinase C), DECR1 (NADPH), and Mox-1 (NADPH oxidase). The oxidation of low density lipoproteins by free radicals is suppressed by the antioxidant action of Ebselen. Ebselen is an inhibitor of Cox-1, Cox-2, NOS, GST and IDO. An inhibitor of 5-LO, 15-LO, Cox, NADPH, and NADPH oxidase.
application：
Ebselen has been used as a:voltage-dependent calcium channels (VDCCs) blocker；glutathione peroxidase mimetic to test its inhibitory effect on contraction-mediated deoxy glucose (2-DG) uptake in mouse；extensor digitorum longus (fast-twitch) muscle
glucocerebrosidase inhibitor；hepatitis C virus helicase inhibitor
1.Minglu Li, Hui Han, Shengmei Song, Shaomin Shuang, Chuan Dong. (2021) AIE-based fluorescent boronate probe and its application in peroxynitrite imaging. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 261 (120044). [PMID:34118522][10.1016/j.saa.2021.120044]
2.Yiming Li, Guanhui Chen, Yi He, Xiliu Zhang, Binghui Zeng, Chao Wang, Chen Yi, Dongsheng Yu. (2019) Ebselen rescues oxidative-stress-suppressed osteogenic differentiation of bone-marrow-derived mesenchymal stem cells via an antioxidant effect and the PI3K/Akt pathway. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 55 (64). [PMID:31345368][10.1016/j.jtemb.2019.06.002]
References
1.Kuschak M, Namasivayam V, Rafehi M, Voss JH, Garg J, Schlegel JG, Abdelrahman A, Kehraus S, Reher R, Küppers J et al.. (2020) Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.. Br J Pharmacol, 177 (8):(1898-1916). [PMID:31881095][10.1021/op500134e]
2.Adeosun SO et al.. (2018) A Novel Fluorescence-Based Assay for the Measurement of Biliverdin Reductase Activity.. React Oxyg Species (Apex), 5 (13):(35-45). [PMID:29379885]
3.Poser SW et al.. (2019) Controlling distinct signaling states in cultured cancer cells provides a new platform for drug discovery.. FASEB J, 33 (8):(9235-9249). [PMID:31145643]
4.Minglu Li, Hui Han, Shengmei Song, Shaomin Shuang, Chuan Dong. (2021) AIE-based fluorescent boronate probe and its application in peroxynitrite imaging. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 261 (120044). [PMID:34118522][10.1016/j.saa.2021.120044]
5.Yiming Li, Guanhui Chen, Yi He, Xiliu Zhang, Binghui Zeng, Chao Wang, Chen Yi, Dongsheng Yu. (2019) Ebselen rescues oxidative-stress-suppressed osteogenic differentiation of bone-marrow-derived mesenchymal stem cells via an antioxidant effect and the PI3K/Akt pathway. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 55 (64). [PMID:31345368][10.1016/j.jtemb.2019.06.002]
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I2403193