Dioscin - analytical standard,≥98%, high purity , CAS No.19057-60-4, Antagonist of CXCR3

Item Number

D114066

Grouped product items
SKU	Size	Availability	Price
D114066-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$69.90
D114066-20mg	20mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$99.90
D114066-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$219.90

Antiproliferative and apoptotic agent

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Basic Description

Synonyms	UNII-3B95U4OLWV \| 3-O-beta-D-alpha-L-Rhamnopyranosyl(1->4)-[alpha-L-rhamnopyranosyl(1->2)]-beta-D-glucopyranoside-diosgenin \| (3.BETA.,25R)-SPIROST-5-EN-3-YL O-6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL-(1->2)-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL-(1->4))-.BETA.-D-GL
Specifications & Purity	Moligand™, analytical standard, ≥98%
Biochemical and Physiological Mechanisms	Antiproliferative and apoptotic agent. Increases caspase-3 and Bax expression. Decreases Bcl-2 expression. Shows membrane disruptive and antifungal effects in vivo.
Shipped In	Normal
Grade	analytical standard, Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of CXCR3
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

IUPAC Name	(2S,3R,4R,5R,6S)-2-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxy-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol
INCHI	InChI=1S/C45H72O16/c1-19-9-14-45(54-18-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(52)34(50)32(48)22(4)56-41)37(53)38(29(17-46)58-42)59-40-35(51)33(49)31(47)21(3)55-40/h7,19-22,24-42,46-53H,8-18H2,1-6H3/t19-,20+,21+,22+,24+,25-,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36-,37+,38-,39-,40+,41+,42-,43+,44+,45-/m1/s1
InChi Key	VNONINPVFQTJOC-ZGXDEBHDSA-N
Canonical SMILES	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)C)O)O)O)O)OC9C(C(C(C(O9)C)O)O)O)C)C)C)OC1
Isomeric SMILES	C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)C)C)C)OC1
Alternate CAS	19057-60-4
PubChem CID	119245
MeSH Entry Terms	dioscin
Molecular Weight	869.05

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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Analytical Chart:

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2 results found

Lot Number	Certificate Type	Date	Item
A1915131	Certificate of Analysis	Jun 06, 2024	D114066
A1527057	Certificate of Analysis	Aug 06, 2022	D114066

Citations of This Product

1. Cao Yongjun, Qiao Nan, Sun Yumeng, Jin Xiaowen, Wen Weibo. (2021) Dioscin alleviates hashimoto’s thyroiditis by regulating the SUMOylation of IRF4 to promote CD4+CD25+Foxp3+ treg cell differentiation. AUTOIMMUNITY, 54 (1): (51-59). [PMID:33274645] [10.1080/08916934.2020.1855428]
2. Qiuyue Ding, Wenda Zhang, Cheng Cheng, Fengbo Mo, Lei Chen, Guangfu Peng, Xianyi Cai, Jinglong Wang, Shuhua Yang, Xianzhe Liu. (2019) Dioscin inhibits the growth of human osteosarcoma by inducing G2/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo. JOURNAL OF CELLULAR PHYSIOLOGY, 235 (3): (2911-2924). [PMID:31535374] [10.1002/jcp.29197]
3. Weixin Zhang, Lianhong Yin, Xufeng Tao, Lina Xu, Lingli Zheng, Xu Han, Youwei Xu, Changyuan Wang, Jinyong Peng. (2016) Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 45 (193). [PMID:27317992] [10.1016/j.etap.2016.06.002]

References

1. Cao Yongjun, Qiao Nan, Sun Yumeng, Jin Xiaowen, Wen Weibo. (2021) Dioscin alleviates hashimoto’s thyroiditis by regulating the SUMOylation of IRF4 to promote CD4+CD25+Foxp3+ treg cell differentiation. AUTOIMMUNITY, 54 (1): (51-59). [PMID:33274645] [10.1080/08916934.2020.1855428]
2. Qiuyue Ding, Wenda Zhang, Cheng Cheng, Fengbo Mo, Lei Chen, Guangfu Peng, Xianyi Cai, Jinglong Wang, Shuhua Yang, Xianzhe Liu. (2019) Dioscin inhibits the growth of human osteosarcoma by inducing G2/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo. JOURNAL OF CELLULAR PHYSIOLOGY, 235 (3): (2911-2924). [PMID:31535374] [10.1002/jcp.29197]
3. Weixin Zhang, Lianhong Yin, Xufeng Tao, Lina Xu, Lingli Zheng, Xu Han, Youwei Xu, Changyuan Wang, Jinyong Peng. (2016) Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 45 (193). [PMID:27317992] [10.1016/j.etap.2016.06.002]

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Basic Description