COH34 - 99%, high purity , CAS No.906439-72-3

Item Number

C648836

Grouped product items
SKU	Size	Availability	Price
C648836-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$166.90
C648836-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$350.90
C648836-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$550.90
C648836-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,650.90
C648836-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,250.90

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Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC 50 of 0.37 nM. COH34 binds to the catalytic domain of PARG ( K d =0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC 50 of 0.37 nM. COH34 binds to the catalytic domain of PARG ( K d =0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors In Vitro COH34 efficiently kills PARP inhibitor-resistant cancer cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.37 nM (PARG)

Names and Identifiers

IUPAC Name	1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol
INCHI	InChI=1S/C18H15NOS/c1-13-6-9-15(10-7-13)21-19-12-17-16-5-3-2-4-14(16)8-11-18(17)20/h2-12,20H,1H3/b19-12+
InChi Key	SFUAIBHPGDRCFL-XDHOZWIPSA-N
Canonical SMILES	CC1=CC=C(C=C1)SN=CC2=C(C=CC3=CC=CC=C32)O
PubChem CID	135443632
NSC Number	191252
Molecular Weight	293.38

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Basic Description