Basic Description

Synonyms	AS-10522 \| C21H26N7O17P3Na4 \| A-NADPH \| HB4469 \| C74369 \| MFCD00036263 \| beta-Nicotinamide adenine dinucleotide phosphate reduced tetrasodium salt \| NADPH tetrasodium salt (reduced form) \| Dihydronicotinamide-adenine dinucleotide phosphate, tetrasodium sa
Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	NADPH, Tetrasodium Salt ia a ubiquitous cofactor and biological reducing agent that acts as an electron donor in many biological reactions. It is generated by reduction of the electron acceptor NADP+, and is very similar to another cofactor, NADH, which l
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Product Description	β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP). A ubiquitous cofactor and biological reducing agent.

AI Insight

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	tetrasodium;[(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-[[[[(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl]oxymethyl]-4-hydroxyoxolan-3-yl] phosphate
INCHI	InChI=1S/C21H30N7O17P3.4Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;;;;/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35);;;;/q;4*+1/p-4/t10-,11-,13-,14-,15-,16-,20-,21-;;;;/m1..../s1
InChi Key	WYWWVJHQDVCHKF-ITGWJZMWSA-J
Canonical SMILES	[Na+].[Na+].[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@H]2O[C@@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](OP([O-])([O-])=O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@H](O)[C@@H]2O
Isomeric SMILES	C1C=CN(C=C1C(=O)N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)([O-])OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O.[Na+].[Na+].[Na+].[Na+]
Molecular Weight	833.35 (anhydrous basis)

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

24 results found

Lot Number	Certificate Type	Date	Item
A2305348	Certificate of Analysis	Oct 23, 2024	C103029
A2305349	Certificate of Analysis	Oct 23, 2024	C103029
A2305350	Certificate of Analysis	Oct 23, 2024	C103029
A2305298	Certificate of Analysis	Oct 16, 2024	C103029
F2404217	Certificate of Analysis	May 24, 2024	C103029
D2415018	Certificate of Analysis	Apr 03, 2024	C103029
G2206494	Certificate of Analysis	Apr 03, 2024	C103029
D2202003	Certificate of Analysis	Jan 08, 2024	C103029
D2202002	Certificate of Analysis	Jan 08, 2024	C103029
K2101072	Certificate of Analysis	Aug 21, 2023	C103029
K2101071	Certificate of Analysis	Aug 21, 2023	C103029
K2101066	Certificate of Analysis	Aug 21, 2023	C103029
J1909174	Certificate of Analysis	May 08, 2023	C103029
D2327017	Certificate of Analysis	Apr 20, 2023	C103029
C2331122	Certificate of Analysis	Apr 11, 2023	C103029
A2424275	Certificate of Analysis	Apr 11, 2023	C103029
C2331152	Certificate of Analysis	Apr 11, 2023	C103029
C2331147	Certificate of Analysis	Apr 11, 2023	C103029
C2331121	Certificate of Analysis	Apr 11, 2023	C103029
E2124118	Certificate of Analysis	Feb 14, 2023	C103029
E2124117	Certificate of Analysis	Feb 14, 2023	C103029
A2305301	Certificate of Analysis	Nov 21, 2022	C103029
J2316019	Certificate of Analysis	Mar 20, 2022	C103029
A2409007	Certificate of Analysis	Mar 20, 2022	C103029

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Safety and Hazards(GHS)

Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
Merck Index	6348

FAQs and Articles

FAQ

Nucleotide Synthesis in Cancer Cells

Categories: Technical articles

Tags:

nucleotide Glycolysis Ribose 5-phosphate TCA cycle

Alcohol dehydrogenase (ADH)

Categories: Technical articles

Tags:

Enzyme Reducing agent NAD NADH NADPH ADH

Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Ni-hong Pang, Ren-ai Xu, Lian-guo Chen, Zhe Chen, Guo-xin Hu, Bo-wen Zhang. (2024) Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes. TOXICOLOGY IN VITRO, 95 (105739). [PMID:38042355] [10.1016/j.tiv.2023.105739]
2. Jianfeng Zhang, Wenrong Bing, Tiancheng Hu, Xu Zhou, Jiejing Zhang, Jing Liang, Yongguang Li. (2023) Enhanced biodegradation of phenol by microbial collaboration: Resistance, metabolite utilization, and pH stabilization. ENVIRONMENTAL RESEARCH, 238 (11): (117269). [PMID:37776942] [10.1016/j.envres.2023.117269]
3. Zhongzhong Lu, Jincong Yan, Guangyue Zu, Mingsheng Xu, Jihuan Liu, Ye Zhang, Lei Shi, Xifeng Fei, Yi Cao, Renjun Pei. (2023) Hypoxia-Responsive T2-to-T1 Dynamically Switchable Extremely Small Iron Oxide Nanoparticles for Sensitive Tumor Imaging In Vivo. BIOCONJUGATE CHEMISTRY, 34 (9): (1622–1632). [PMID:37584604] [10.1021/acs.bioconjchem.3c00285]
4. Pengyi Chen, Chengguo Pang, Tianen Xu, Peiliang Dong, Hua Han. (2023) Characterization of chemical constituents and metabolites in vivo and in vitro after oral administration of Wuteng tablets in rats by UHPLC–Q/TOF–MS. BIOMEDICAL CHROMATOGRAPHY, 37 (10): (e5704). [PMID:37496363] [10.1002/bmc.5704]
5. Liu Lang, Wang Suji, Zuo Junfeng, Zhang Xiaohe, Peng Xiong, Wang Kang, Chen Maohua. (2023) Characterization and fitness cost of bifenthrin resistance in Rhopalosiphum padi (Hemiptera: Aphididae). JOURNAL OF ECONOMIC ENTOMOLOGY, [PMID:37478406] [10.1093/jee/toad143]
6. Jia Huang, Guiming Deng, Shuya Wang, Tianjiao Zhao, Qiaohui Chen, Yuqi Yang, Yongqi Yang, Jinping Zhang, Yayun Nan, Zhaoqian Liu, Ke Cao, Qiong Huang, Kelong Ai. (2023) A NIR-II Photoactivatable “ROS Bomb” with High-Density Cu2O-Supported MoS2 Nanoflowers for Anticancer Therapy. Advanced Science, (2302208). [PMID:37340606] [10.1002/advs.202302208]
7. Kai Wang, Wentao Zhou, Xiangyu Jin, Xuwei Shang, Xiaomei Wu, Lijuan Wen, Sufen Li, Yiling Hong, Jia Ke, Yichong Xu, Hong Yuan, Fuqiang Hu. (2023) Enhanced brain delivery of hypoxia-sensitive liposomes by hydroxyurea for rescue therapy of hyperacute ischemic stroke. Nanoscale, 15 (27): (11625-11646). [PMID:37377137] [10.1039/D3NR01071F]
8. Dingyue Zhang, Lixia Dong, Wenyong Yang, Kui Wang, Dingyue Zhang, Lixia Dong, Wenyong Yang, Kui Wang. (2023) Identification of NQO1 as a target of herbal drug agrimol B in hepatocellular carcinoma. AUSTRALIAN JOURNAL OF CHEMISTRY, 76 (8): (465-475). [PMID:] [10.1071/CH22255]
9. Shuanghu Wang, Mengming Xia, Yu Wang, Zebei Lu, Peiwu Geng, Dapeng Dai, Yunfang Zhou, Qingjun Wu. (2023) Inhibitory effect of Schisandrin on the pharmacokinetics of poziotinib in vivo and in vitro by UPLC-MS/MS. Thoracic Cancer, 14 (14): (1276-1285). [PMID:36973912] [10.1111/1759-7714.14870]
10. Min-Yu Wang, Shun-Ju Cai, Jia-Chun Lin, Xiao-Jun Ji, Zhi-Gang Zhang. (2023) New Anti-Prelog Stereospecific Whole-Cell Biocatalyst for Asymmetric Reduction of Prochiral Ketones. MOLECULES, 28 (3): (1422). [PMID:36771091] [10.3390/molecules28031422]
11. Fangying Yu, Xuwei Shang, Zixu Wang, Yun Zhu, Simin Chen, Hong Yuan, Fuqiang Hu. (2023) Drug-independent NADPH-consuming micelles collaborate with ROS-generator for cascade ferroptosis amplification by impairing redox homeostasis. Materials Today Bio, 18 (100532). [PMID:36691607] [10.1016/j.mtbio.2022.100532]
12. Bin Huang, Kai Yang, Charles Amanze, Zhen Yan, Hongbo Zhou, Xueduan Liu, Guanzhou Qiu, Weimin Zeng. (2023) Sequence and structure-guided discovery of a novel NADH-dependent 7β-hydroxysteroid dehydrogenase for efficient biosynthesis of ursodeoxycholic acid. BIOORGANIC CHEMISTRY, 131 (106340). [PMID:36586301] [10.1016/j.bioorg.2022.106340]
13. Shujing Xu, Lin Sun, Dang Ding, Xujie Zhang, Xinyong Liu, Peng Zhan. (2022) Metabolite Identification of HIV-1 Capsid Modulators PF74 and 11L in Human Liver Microsomes. Metabolites, 12 (8): (752). [PMID:36005624] [10.3390/metabo12080752]
14. Yaxuan Qian, Zhuoran Jiang, Yan Long, Houguo Fei, Heng Song, Cunlan Guo. (2022) Electroenzymatic Aromatic Nitration via an Electric Field and Electro-Mediator. ACS Sustainable Chemistry & Engineering, 10 (20): (6667–6674). [PMID:] [10.1021/acssuschemeng.2c00523]
15. Yixiang Li, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai. (2021) Characterization of a putative tropinone reductase from Tarenaya hassleriana with a broad substrate specificity. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 69 (6): (2530-2539). [PMID:34902878] [10.1002/bab.2302]
16. Xueqing Yang, Xinru Li, Xinzhu Cang, Jianglong Guo, Xiujing Shen, Kongming Wu. (2021) Influence of seasonal migration on the development of the insecticide resistance of oriental armyworm (Mythimna separata) to λ-cyhalothrin. PEST MANAGEMENT SCIENCE, 78 (3): (1194-1205). [PMID:34825453] [10.1002/ps.6736]
17. Jiawei Guo, Fengwei Li, Fangyuan Cheng, Li Ma, Xiaohui Liu, Pradeepraj Durairaj, Gang Zhang, Dandan Tang, Xiangtian Long, Wei Zhang, Lei Du, Xingwang Zhang, Shengying Li. (2021) Bacterial Biosynthetic P450 Enzyme PikCD50N: A Potential Biocatalyst for the Preparation of Human Drug Metabolites. JOURNAL OF ORGANIC CHEMISTRY, 86 (21): (14563–14571). [PMID:34662127] [10.1021/acs.joc.1c01407]
18. Yun-Jing Zhang, Wen-Li Zhou, Fei Yu, Qian Wang, Can Peng, Jia-Yi Kan. (2021) Evaluation of the effect of Bovis Calculus Artifactus on eight rat liver cytochrome P450 isozymes using LC-MS/MS and cocktail approach. XENOBIOTICA, 51 (9): (1010-1018). [PMID:34294011] [10.1080/00498254.2021.1959673]
19. Yidong Zhou, Siyuan Gao, Mingliang Zhang, Wankui Jiang, Zhijian Ke, Jiguo Qiu, Jianhong Xu, Qing Hong. (2021) Unveiling the CoA mediated salicylate catabolic mechanism in Rhizobium sp. X9. MOLECULAR MICROBIOLOGY, 116 (3): (783-793). [PMID:34121246] [10.1111/mmi.14771]
20. Fangying Yu, Xuwei Shang, Yun Zhu, Haiya Lou, Yupeng Liu, Tingting Meng, Yun Hong, Hong Yuan, Fuqiang Hu. (2021) Self-preparation system using glucose oxidase-inspired nitroreductase amplification for cascade-responsive drug release and multidrug resistance reversion. BIOMATERIALS, 275 (120927). [PMID:34119887] [10.1016/j.biomaterials.2021.120927]
21. Yang Tian, Wen-Li Jiang, Wen-Xin Wang, Guo-Jiang Mao, Yongfei Li, Chun-Yan Li. (2021) NAD(P)H-triggered probe for dual-modal imaging during energy metabolism and novel strategy of enhanced photothermal therapy in tumor. BIOMATERIALS, 271 (120736). [PMID:33662745] [10.1016/j.biomaterials.2021.120736]
22. Xiaoxiang Hu, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai. (2020) A novel type alanine dehydrogenase from Helicobacter aurati: Molecular characterization and application. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 161 (636). [PMID:32534087] [10.1016/j.ijbiomac.2020.06.067]
23. Yanxia Zhu, Jun Cheng, Ze Zhang, Jianzhong Liu. (2020) Mutation of Arthrospira platensis by gamma irradiation to promote phenol tolerance and CO2 fixation for coal-chemical flue gas reduction. Journal of CO2 Utilization, 38 (252). [PMID:] [10.1016/j.jcou.2020.02.003]
24. Bing-Mei Su, Ze-Hui Shao, Ai-Peng Li, Muhammad Naeem, Juan Lin, Li-Dan Ye, Hong-Wei Yu. (2020) Rational Design of Dehydrogenase/Reductases Based on Comparative Structural Analysis of Prereaction-State and Free-State Simulations for Efficient Asymmetric Reduction of Bulky Aryl Ketones. ACS Catalysis, 10 (1): (864–876). [PMID:] [10.1021/acscatal.9b04778]
25. Hongqiu Zhou, Li Yang, Changsuo Wang, Zhiqiang Li, Zhen Ouyang, Mangting Shan, Jun Gu, Yuan Wei. (2019) CYP2D1 Gene Knockout Reduces the Metabolism and Efficacy of Venlafaxine in Rats. DRUG METABOLISM AND DISPOSITION, 47 (12): (1425-1432). [PMID:31658948] [10.1124/dmd.119.088526]
26. Bayarmaa Khadankhuu, Yuxiang Fei, Dan Xu, Yingchao Li, Kai Hou, Fengyang Li, Weirong Fang, Xijing Chen, Yunman Li. (2020) Pharmacokinetics and pharmacodynamics analysis of XQ-1H and its combination therapy with clopidogrel on cerebral ischemic reperfusion injury in rats. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 179 (112975). [PMID:31735472] [10.1016/j.jpba.2019.112975]
27. Fanpeng Kong, Ying Li, Chao Yang, Xiao Li, Junlin Wu, Xiaojun Liu, Xiaonan Gao, Kehua Xu, Bo Tang. (2019) A fluorescent probe for simultaneously sensing NTR and hNQO1 and distinguishing cancer cells. Journal of Materials Chemistry B, 7 (43): (6822-6827). [PMID:31608921] [10.1039/C9TB01581G]
28. Fei-Long Li, Qiang Zhou, Wei Wei, Jian Gao, Ye-Wang Zhang. (2019) Switching the substrate specificity from NADH to NADPH by a single mutation of NADH oxidase from Lactobacillus rhamnosus. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 135 (328). [PMID:31128193] [10.1016/j.ijbiomac.2019.05.146]
29. Zi-Guo Wang, Shan-Shan Jiang, David Mota-Sanchez, Wei Wang, Xin-Ru Li, Yu-Lin Gao, Xu-Peng Lu, Xue-Qing Yang. (2019) Cytochrome P450-Mediated λ-Cyhalothrin-Resistance in a Field Strain of Helicoverpa armigera from Northeast China. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 67 (13): (3546–3553). [PMID:30882220] [10.1021/acs.jafc.8b07308]
30. Jie Liu, Yuli Wang, Xiaoxue Liu, Qunhui Yuan, Yang Zhang, Yingchun Li. (2019) Novel molecularly imprinted polymer (MIP) multiple sensors for endogenous redox couples determination and their applications in lung cancer diagnosis. TALANTA, 199 (573). [PMID:30952300] [10.1016/j.talanta.2019.03.018]
31. Huanying Ye, Danjuan Sui, Wei Liu, Yuannan Yuan, Zhen Ouyang, Yuan Wei. (2019) Effects of CYP2C11 gene knockout on the pharmacokinetics and pharmacodynamics of warfarin in rats. XENOBIOTICA, 49 (12): (1478-1484). [PMID:30724651] [10.1080/00498254.2019.1579006]
32. Miao Yan, Zhu-feng Wu, Dan Tang, Feng Wang, Yi-wen Xiao, Ping Xu, Bi-kui Zhang, Yi-ping Liu, Da-xiong Xiang, Hoan Linh Banh. (2018) The impact of proton pump inhibitors on the pharmacokinetics of voriconazole in vitro and in vivo. BIOMEDICINE & PHARMACOTHERAPY, 108 (60). [PMID:30216801] [10.1016/j.biopha.2018.08.121]
33. Wang Zhiwei, Bu Yibin, Zhao Yonghe, Zhang Zuotai, Liu Lifen, Zhou Hao. (2018) Morphology-tunable tellurium nanomaterials produced by the tellurite-reducing bacterium Lysinibacillus sp. ZYM-1. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 25 (21): (20756-20768). [PMID:29756181] [10.1007/s11356-018-2257-y]
34. Zheng Liandan, Lin Jinping, Zhang Baoqi, Kuang Yuyao, Wei Dongzhi. (2018) Identification of a yeast old yellow enzyme for highly enantioselective reduction of citral isomers to (R)-citronellal. Bioresources and Bioprocessing, 5 (1): (1-12). [PMID:] [10.1186/s40643-018-0192-x]
35. Chen Zhao, Yan Yang, Linfang Wei, Qinghua Guo, Hao Fang, Shaolin Chen, Qiang Hua. (2017) Simultaneous determination of intracellular nucleotides and coenzymes in Yarrowia lipolytica producing lipid and lycopene by capillary zone electrophoresis. JOURNAL OF CHROMATOGRAPHY A, 1514 (120). [PMID:28760603] [10.1016/j.chroma.2017.07.074]
36. Min Li, Zheng Zhou, Zhi-Jun Zhang, Hui-Lei Yu, Jian-He Xu. (2016) Biochemical properties of a new nitrile reductase cloned from Pectobacterium carotovorum. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 131 (47). [PMID:] [10.1016/j.molcatb.2016.06.001]
37. Rui Cai,Yahong Yuan,Zhouli Wang,Chunfeng Guo,Bin Liu,Laping Liu,Yutang Wang,Tianli Yue. (2015-08-05) Precursors and metabolic pathway for guaiacol production by Alicyclobacillus acidoterrestris.. International journal of food microbiology, 214 (48-53). [PMID:26241489]
38. Kunpeng Li,Rongzhen Zhang,Yan Xu,Zhimeng Wu,Jing Li,Xiaotian Zhou,Jiawei Jiang,Haiyan Liu,Rong Xiao. (2017-06-10) Sortase A-mediated crosslinked short-chain dehydrogenases/reductases as novel biocatalysts with improved thermostability and catalytic efficiency.. Scientific reports, 7 ((1)): (3081-3081). [PMID:28596548]
39. Zhou, et al.. (2021) Hydrolase CehA and a Novel Two-Component 1-Naphthol Hydroxylase CehC1C2 are Responsible for the Two Initial Steps of Carbaryl Degradation in Rhizobium sp. X9.. Journal of Agricultural and Food Chemistry, 68 (14739-14747). [PMID:33264024]

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Coenzyme II reduced tetrasodium salt - 95%, high purity , CAS No.2646-71-1