| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| C274997-10mg | 10mg | 3 | $127.90 | |
| C274997-50mg | 50mg | 3 | $395.90 | |
| C274997-250mg | 250mg | 3 | $1,782.90 |
Potent, broad spectrum votage gate Na + channel blocker
| Synonyms | NCGC00167807-01 | BCP32511 | J-011566 | HMS3677N07 | MS-23875 | FPhOBal semicarbazone | 0KN11H90GF | 2-(4-(4-Fluorophenoxy)benzylidene)hydrazinecarboxamide | UNII-0KN11H90GF | Ethylene, 1,1-bis(p-chlorophenyl)-2-chloro- | AKOS016004881 | A920653 | CO-1028 |
|---|---|
| Specifications & Purity | ≥99% |
| Biochemical and Physiological Mechanisms | Potent, broad spectrum voltage gate Na + channel blocker (K i value = 600 nM). Displays ~ 80-fold higher affinity for the inactivated compared to resting state channels. Orally active. Anticonvulsant. Active in vivo and in vitro . |
| Storage Temp | Store at -20°C,Desiccated |
| Shipped In | Ice chest + Ice pads |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. Application： Co 102862 (cas# 181144-66-1) is a useful research chemical. Co 102862 is an orally active anticonvulsant with robust activity in a variety of rodent models of epilepsy. Inhibition of voltage-gated Na+ channels is a major mechanism underlying the anticonvulsant properties of Co 102862. |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Pubchem Sid | 504764901 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504764901 |
| IUPAC Name | [(E)-[4-(4-fluorophenoxy)phenyl]methylideneamino]urea |
| INCHI | InChI=1S/C14H12FN3O2/c15-11-3-7-13(8-4-11)20-12-5-1-10(2-6-12)9-17-18-14(16)19/h1-9H,(H3,16,18,19)/b17-9+ |
| InChi Key | MHUUDVZSPFRUSK-RQZCQDPDSA-N |
| Canonical SMILES | C1=CC(=CC=C1C=NNC(=O)N)OC2=CC=C(C=C2)F |
| Isomeric SMILES | C1=CC(=CC=C1/C=N/NC(=O)N)OC2=CC=C(C=C2)F |
| PubChem CID | 9816959 |
| Molecular Weight | 273.3 |
H2223480