| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| C408210-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $349.90 |
Precursor ofcalcifediol(Cat. No. 4036). Naturally occurring form of vitamin D
| Synonyms | Cholecalciferol, Colecalciferol | Cyclohexanol, 3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-1,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1S,3Z)- |
|---|---|
| Specifications & Purity | Moligand™, 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Cholecalciferol (Vitamin D3, Cholecalciferol, Colecalciferol) is a form of vitamin D, binds and activates a H305F/H397Y mutant vitamin D receptor (VDR) with EC50 of 300 nM. |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Product Description | Information Cholecalciferol (Vitamin D3, Cholecalciferol, Colecalciferol) is a form of vitamin D, binds and activates a H305F/H397Y mutant vitamin D receptor (VDR) withEC50of 300 nM. Vitamin D3 is a fat-soluble vitamin that helps your body absorb calcium and phosphorus. Vitamin D3, a precursor in the 1α,25- dihydroxyvitamin D3 biosynthetic pathway, which does not activate wild-type hVDR. It binds and activates H305F/H397Y variant hVDR ,with 70 fold activation in compare to wide-type hVDR. Epidemiological studies and work on experimental animals strongly suggest a protective effect of cholecalciferol vitamin D3 (1,25(OH)2D3) against colon cancer and several other cancers. In vivo With UV-radiation, vitamin D3 is synthesized in the skin from the precursors 7-dehydro-cholesterole and provitamin D3. In the liver, vitamin D3 is transformed to 25-hydroxyvitamin D3. Six cytochrome P450 hydroxylases can exhibit this 25-hydroxylation, with the main enzyme being CYP27A1 (25-hydroxylase). The subsequent step is a 1alpha-hydroxylation by CYP27B1 (1-hydroxylase), which produces the most active form of vitamin D3, 1,25-dihydroxyvitamin-D3. This metabolite is inactivated by a 24-hydroxylation by CYP24 (24-hydro-xylase). Vitamin D3 is used for prevention of mortality in adults. However, Vitamin D3 combines with calcium increased the risk of nephrolithiasis. cell lines： Concentrations：~ 100 nM Incubation Time：~ 96 h Powder Purity: |
| Canonical SMILES | CC(C)CCCC(C)C1CCC2/C(CCCC12C)=C/C=C3/CC(O)CCC3=C |
|---|---|
| Molecular Weight | 384.64 |
| 1. Ying-zhuo Shen, Zheng Wang, Kangping Ning, Chuanli Ren, Dandan Yang, Xiao-Ya Hu, Qin Xu. (2023) Ultrasensitive alkaline phosphatase activity assay based on controllable signal probe production coupled with the cathodic photoelectrochemical analysis. FOOD CHEMISTRY, 421 (136177). [PMID:37094400] [10.1016/j.foodchem.2023.136177] |
| 1. Ying-zhuo Shen, Zheng Wang, Kangping Ning, Chuanli Ren, Dandan Yang, Xiao-Ya Hu, Qin Xu. (2023) Ultrasensitive alkaline phosphatase activity assay based on controllable signal probe production coupled with the cathodic photoelectrochemical analysis. FOOD CHEMISTRY, 421 (136177). [PMID:37094400] [10.1016/j.foodchem.2023.136177] |
