Brassinolide is a plant hormone; a natural steroid containing a seven-membered B-ring lactone, that promotes both cell elongation and cell devision and is used as a plant growth regulator. Description: IC50 Value: N/A Brassinolide is a plant sterol first isolated from pollen of rape (Brassica napus L.), Brassinolide could promote stem elongation and cell division. in vitro: Caspase-3 activity was obviously increased after brassinolide treatment. Western blot studies indicated that treatment with brassinolide triggered a time-dependent decrease in the expression of anti-apoptotic protein Bcl-2 [1]. After treatment of brassinolide under the concentration of 0.001 - 10.0 microg x mL(-1), the resistance of CCRF-VCR was reversed partly with the reversing folds respectively as 4.4 - 11.6 [2]. After brassinolide treatment, the expression of p53 in CCRF-VCR cells restored to the level of sensitive cells. in vivo: After oral administration of Brassinolide for consecutive 7 days(once every day),the levels of blood glucose were evaluated on the day 0 and the day 7 [3]. Clinical trial: N/A
1.Zhong Ximing, Lan Ruopeng, Su Guofeng, Hao Li, Xu Hua, Zhou Hongjun, Zhou Xinhua. (2023) Enhancing the salt stress resistance of seeds and seedlings via a brassinolide sustained release agent system. Chemical and Biological Technologies in Agriculture, 10 (1):(1-16). [PMID:17109758][10.1186/s40538-023-00510-8]
2.Zheping Yu, Shuwen Zhang, Li Sun, Senmiao Liang, Xiliang Zheng, Haiying Ren, Xingjiang Qi. (2024) Effects of Enhanced Resistance and Transcriptome Analysis of Twig Blight Disease by Exogenous Brassinolide in Myrica rubra. Antioxidants, 13 (1):(61). [PMID:38247485][10.3390/antiox13010061]
3.Zhang Ting, Zhao Yichen. (2023) Cloning and characterization of the BZR1-2 promoter from Camellia sinensis and its responses to hormonal and abiotic stresses. PLANT CELL TISSUE AND ORGAN CULTURE, (1-11). [PMID:][10.1007/s11240-023-02592-6]
4.Basit Farwa, Liu Jiaxin, An Jianyu, Chen Min, He Can, Zhu Xiaobo, Li Zhan, Hu Jin, Guan Yajing. (2022) Seed priming with brassinosteroids alleviates aluminum toxicity in rice via improving antioxidant defense system and suppressing aluminum uptake. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 29 (7):(10183-10197). [PMID:34515933][10.1007/s11356-021-16209-y]
5.Zilong Cui, Zhiruo Zhao, Liang Yao, Yonghong Hu. (2021) Determination and analysis of solubility of brassinolide in different solvent systems at different temperatures (T = 278.15–323.15 K). JOURNAL OF MOLECULAR LIQUIDS, 340 (117316). [PMID:][10.1016/j.molliq.2021.117316]
6.Yang Ding, Jiping Sheng, Fansheng Cheng. (2021) Assessment of the role of brassinosteroid in regulating the disease resistance of postharvest tomato fruit by proteomic analysis. JOURNAL OF FOOD PROCESSING AND PRESERVATION, 45 (9):(e15708). [PMID:][10.1111/jfpp.15708]
7.Yunlei Zhou, Huanshun Yin, Yue Wang, Chengji Sui, Minghui Wang, Shiyun Ai. (2018) Electrochemical aptasensors for zeatin detection based on MoS2 nanosheets and enzymatic signal amplification. ANALYST, 143 (21):(5185-5190). [PMID:30264075][10.1039/C8AN01356J]
References
1.Zhong Ximing, Lan Ruopeng, Su Guofeng, Hao Li, Xu Hua, Zhou Hongjun, Zhou Xinhua. (2023) Enhancing the salt stress resistance of seeds and seedlings via a brassinolide sustained release agent system. Chemical and Biological Technologies in Agriculture, 10 (1):(1-16). [PMID:17109758][10.1186/s40538-023-00510-8]
2.Zheping Yu, Shuwen Zhang, Li Sun, Senmiao Liang, Xiliang Zheng, Haiying Ren, Xingjiang Qi. (2024) Effects of Enhanced Resistance and Transcriptome Analysis of Twig Blight Disease by Exogenous Brassinolide in Myrica rubra. Antioxidants, 13 (1):(61). [PMID:38247485][10.3390/antiox13010061]
3.Zhang Ting, Zhao Yichen. (2023) Cloning and characterization of the BZR1-2 promoter from Camellia sinensis and its responses to hormonal and abiotic stresses. PLANT CELL TISSUE AND ORGAN CULTURE, (1-11). [PMID:][10.1007/s11240-023-02592-6]
4.Basit Farwa, Liu Jiaxin, An Jianyu, Chen Min, He Can, Zhu Xiaobo, Li Zhan, Hu Jin, Guan Yajing. (2022) Seed priming with brassinosteroids alleviates aluminum toxicity in rice via improving antioxidant defense system and suppressing aluminum uptake. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 29 (7):(10183-10197). [PMID:34515933][10.1007/s11356-021-16209-y]
5.Zilong Cui, Zhiruo Zhao, Liang Yao, Yonghong Hu. (2021) Determination and analysis of solubility of brassinolide in different solvent systems at different temperatures (T = 278.15–323.15 K). JOURNAL OF MOLECULAR LIQUIDS, 340 (117316). [PMID:][10.1016/j.molliq.2021.117316]
6.Yang Ding, Jiping Sheng, Fansheng Cheng. (2021) Assessment of the role of brassinosteroid in regulating the disease resistance of postharvest tomato fruit by proteomic analysis. JOURNAL OF FOOD PROCESSING AND PRESERVATION, 45 (9):(e15708). [PMID:][10.1111/jfpp.15708]
7.Yunlei Zhou, Huanshun Yin, Yue Wang, Chengji Sui, Minghui Wang, Shiyun Ai. (2018) Electrochemical aptasensors for zeatin detection based on MoS2 nanosheets and enzymatic signal amplification. ANALYST, 143 (21):(5185-5190). [PMID:30264075][10.1039/C8AN01356J]
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