BQ-123 - 98%, high purity , CAS No.136553-81-6, Antagonist of ET A receptor

Item Number

B275090

Grouped product items
SKU	Size	Availability	Price
B275090-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$99.90
B275090-5mg	5mg	3	$395.90
B275090-10mg	10mg	2	$692.90
B275090-25mg	25mg	2	$1,559.90
B275090-50mg	50mg	2	$2,806.90
B275090-100mg	100mg	2	$5,051.90

Potent, selective ET A receptor antagonist

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Basic Description

Synonyms	2-((3R,6S,9R,12R,17aS)-9-((1H-indol-3-yl)methyl)-6-isobutyl-3-isopropyl-1,4,7,10,13-pentaoxohexadecahydro-1H-pyrrolo[1,2-a][1,4,7,10,13]pentaazacyclopentadecin-12-yl)acetic acid \| cyclo(L-Leu-D-Trp-D-Asp-L-Pro-D-Val) \| BDBM50197954 \| LS-13503 \| B-186 \| BQ
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Potent, selective ET A receptor antagonist (IC 50 values are 7.3 and 18,000 nM for ET A and ET B endothelin receptors respectively). Some ability to cross the blood-brain barrier. Anti-ischemic activity in vivo .
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of ET A receptor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

Pubchem Sid	504758796
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504758796
IUPAC Name	2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid
INCHI	InChI=1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1
InChi Key	VYCMAAOURFJIHD-PJNXIOHISA-N
Canonical SMILES	CC(C)CC1C(=O)NC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43
Isomeric SMILES	CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(=O)N1)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43
PubChem CID	443289
Molecular Weight	610.7

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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Analytical Chart:

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6 results found

Lot Number	Certificate Type	Date	Item
K2218158	Certificate of Analysis	Aug 25, 2022	B275090
K2218163	Certificate of Analysis	Aug 25, 2022	B275090
K2218171	Certificate of Analysis	Aug 25, 2022	B275090
K2218172	Certificate of Analysis	Aug 25, 2022	B275090
K2218174	Certificate of Analysis	Aug 25, 2022	B275090
K2218188	Certificate of Analysis	Aug 25, 2022	B275090

References

1. Maayah ZH et al.. (2020) Breast cancer diagnosis is associated with relative left ventricular hypertrophy and elevated endothelin-1 signaling.. BMC Cancer, 20 (751). [PMID:32787791]
2. Wu Q et al.. (2018) CT perfusion imaging of cerebral microcirculatory changes following subarachnoid hemorrhage in rabbits: Specific role of endothelin-1 receptor antagonist.. Brain Res, 1701 (196-203). [PMID:30244111]
3. Kobayashi Y et al.. (2021) Early manifestations and differential gene expression associated with photoreceptor degeneration in Prom1-deficient retina.. Dis Model Mech, 14 (11): [PMID:34664634]
4. Furukawa A et al.. (2018) Endothelin Signaling Contributes to Modulation of Nociception in Early-stage Tongue Cancer in Rats.. Anesthesiology, 128 (6): (1207-1219). [PMID:29461271]

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Basic Description