| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| B288896-10mg | 10mg | 3 | $112.90 | |
| B288896-50mg | 50mg | 2 | $508.90 | |
| B288896-100mg | 100mg | 2 | $915.90 | |
| B288896-250mg | 250mg | 2 | $2,059.90 | |
| B288896-1g | 1g | 2 | $7,413.90 |
Selective allosteric glutaminase (GLS1) inhibitor
| Synonyms | AKOS027470168 | SNX1770 | SNX-1770 | A14954 | 4jkt | BDBM50400050 | EX-A2297 | 2,2'-(5,5'-(2,2'-thiobis(ethane-2,1-diyl))bis(1,3,4-thiadiazole-5,2-diyl))bis(azanediyl)bis(1-phenylethanone) | HY-12683 | HMS3866K13 | EN300-127250 | 3uo9 | BPTES, >=95% (HPLC |
|---|---|
| Specifications & Purity | ≥95%(HPLC) |
| Biochemical and Physiological Mechanisms | Allosteric glutaminase (GLS1) inhibitor (IC50= 3.3μM). Selective for GLS1 over GLS2 andγ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cellsin vitroand reduces tumor volume of P493 cell xenografts in mice. Vaccinia virus (VACV) requ |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Product application: Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) has been used as a glutaminase inhibitor. |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Pubchem Sid | 504762547 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504762547 |
| IUPAC Name | 2-phenyl-N-[5-[2-[2-[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]ethylsulfanyl]ethyl]-1,3,4-thiadiazol-2-yl]acetamide |
| INCHI | InChI=1S/C24H24N6O2S3/c31-19(15-17-7-3-1-4-8-17)25-23-29-27-21(34-23)11-13-33-14-12-22-28-30-24(35-22)26-20(32)16-18-9-5-2-6-10-18/h1-10H,11-16H2,(H,25,29,31)(H,26,30,32) |
| InChi Key | MDJIPXYRSZHCFS-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC=C(C=C1)CC(=O)NC2=NN=C(S2)CCSCCC3=NN=C(S3)NC(=O)CC4=CC=CC=C4 |
| Isomeric SMILES | C1=CC=C(C=C1)CC(=O)NC2=NN=C(S2)CCSCCC3=NN=C(S3)NC(=O)CC4=CC=CC=C4 |
| WGK Germany | 3 |
| PubChem CID | 3372016 |
| Molecular Weight | 524.68 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 J2209042 | Certificate of Analysis | Jul 25, 2022 | B288896 |
| J2209043 | Certificate of Analysis | Jul 25, 2022 | B288896 |
| J2209044 | Certificate of Analysis | Jul 25, 2022 | B288896 |
| J2209045 | Certificate of Analysis | Jul 25, 2022 | B288896 |
| J2209049 | Certificate of Analysis | Jul 25, 2022 | B288896 |
| K2411116 | Certificate of Analysis | Jul 25, 2022 | B288896 |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| RIDADR | NONHforallmodesoftransport |
