| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| N130534-1mg | 1mg | 3 | $24.90 | |
| N130534-5mg | 5mg | 3 | $95.90 | |
| N130534-10mg | 10mg | 3 | $171.90 | |
| N130534-25mg | 25mg | 3 | $384.90 |
Potent, selective PLD2 inhibitor
| Synonyms | VU0285655-1 | APV |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | Potent, selective PLD2 inhibitor (IC 50 values are 90 and 500 nM for HEK293 and human cells respectively). |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Pubchem Sid | 504770278 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504770278 |
| IUPAC Name | N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]quinoline-3-carboxamide |
| INCHI | InChI=1S/C25H27N5O2/c31-23(20-16-19-6-4-5-9-22(19)27-17-20)26-12-15-29-13-10-25(11-14-29)24(32)28-18-30(25)21-7-2-1-3-8-21/h1-9,16-17H,10-15,18H2,(H,26,31)(H,28,32) |
| InChi Key | WJOCDBUFEUKYNI-UHFFFAOYSA-N |
| Canonical SMILES | C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCNC(=O)C4=CC5=CC=CC=C5N=C4 |
| Isomeric SMILES | C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCNC(=O)C4=CC5=CC=CC=C5N=C4 |
| PubChem CID | 44138050 |
| Molecular Weight | 429.5 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 F2316511 | Certificate of Analysis | Mar 04, 2025 | N130534 |
| F2316549 | Certificate of Analysis | Mar 04, 2025 | N130534 |
| F2316552 | Certificate of Analysis | Mar 04, 2025 | N130534 |
| F2316553 | Certificate of Analysis | Mar 04, 2025 | N130534 |
| F2316555 | Certificate of Analysis | Mar 04, 2025 | N130534 |
| F2316556 | Certificate of Analysis | Mar 04, 2025 | N130534 |
| F2316558 | Certificate of Analysis | Mar 04, 2025 | N130534 |
| F2316559 | Certificate of Analysis | Mar 04, 2025 | N130534 |
| 1. Chakraborti S et al.. (2019) Role of PLD-PKCζ signaling axis in p47phox phosphorylation for activation of NADPH oxidase by angiotensin II in pulmonary artery smooth muscle cells.. Cell Biol Int, 43 (6): (678-694). [PMID:30977575] |
