BI-4142 - 98%, high purity , CAS No.2682003-36-5, Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2

Item Number

B608049

Grouped product items
SKU	Size	Availability	Price
B608049-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$249.90
B608049-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$600.90
B608049-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,299.90
B608049-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,700.90
B608049-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,299.90

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Basic Description

Synonyms	BI4142;compound 8;example L-1
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at 2-8°C,Protected from light
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2
Product Description	BI-4142 is a potent, highly selective and orally active HER2 inhibitor with an IC50 of 5 nM.

Canonical SMILES

O=C(N1CCN(CC1)C2=NC=C3N=CN=C(C3=N2)NC4=CC=C(C(C)=C4)OC5=CC(N=CN6C)=C6C=C5)C=C

Molecular Weight

521.57

References

1. Wilding B, Scharn D, Böse D, Baum A, Santoro V, Chetta P, Schnitzer R, Botesteanu DA, Reiser C, Kornigg S et al.. (2022) Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling.. Nat Cancer, 3 (7): (821-836). [PMID:35883003] [10.1021/op500134e]

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Basic Description