Bexarotene - ≥99%, high purity , Retinoid X receptor agonist, CAS No.153559-49-0, Retinoid X receptor agonist

Item Number
B125743
Grouped product items
SKUSizeAvailabilityPrice Qty
B125743-50mg
50mg
3
$35.90
B125743-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$49.90
B125743-250mg
250mg
1
$263.90
B125743-1g
1g
1
$947.90

Potent RXR agonist

Basic Description

SynonymsBEXAROTENE [MART.] | Bexarotene [USAN:INN:BAN] | 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid | L01XX25 | NCGC00255426-01 | NCGC00181016-08 | NSC 747528 | AC-24569 | HMS3884B07 | Targretin | Ro 26-4455 | LGD1069 | LGD-1069 |
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsBexarotene (tradenamed Targretin) is an oral antineoplastic agent indicated by the U.S. Food and Drug Administration (FDA) (in 2000) for cutaneous T cell lymphoma. Bexarotene (tradenamed Targretin) has been used off-label for lung cancer, breast cancer, a
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST, ANTAGONIST
Mechanism of actionRetinoid X receptor agonist
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Bexarotene (Targretin) is a selective RXR agonist approved for the treatment of CTCL.
A selective agonist of retinoid X receptors

AI Insight

Product Properties

ALogP7.6

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid504755581
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504755581
IUPAC Name 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid
INCHI InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
InChi Key NAVMQTYZDKMPEU-UHFFFAOYSA-N
Canonical SMILES CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C
Isomeric SMILES CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C
WGK Germany 3
PubChem CID 82146
Molecular Weight 348.48

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeDateItem
G1824280Certificate of AnalysisDec 12, 2023 B125743
K2314279Certificate of AnalysisNov 02, 2023 B125743
K2314280Certificate of AnalysisNov 02, 2023 B125743
K2314281Certificate of AnalysisNov 02, 2023 B125743
K2314282Certificate of AnalysisNov 02, 2023 B125743
F1601005Certificate of AnalysisOct 18, 2023 B125743
I2213251Certificate of AnalysisSep 16, 2022 B125743

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P318:if exposed or concerned, get medical advice.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
Merck Index 1194

Related Documents

Reviews

Customer Reviews

References

1. Liu H et al..  (2019)  Bexarotene Attenuates Focal Cerebral Ischemia-Reperfusion Injury via the Suppression of JNK/Caspase-3 Signaling Pathway..  Neurochem Res,  44  (12): (2809-2820).  [PMID:31680194]
2. Liu H et al..  (2022)  iTRAQ-derived quantitative proteomics uncovers the neuroprotective property of bexarotene in a mice model of cerebral ischemia-reperfusion injury..  Saudi Pharm J,  30  (5): (585-594).  [PMID:35693438]

Solution Calculators