AZD4877 , Kinesin-like protein 1 inhibitor, CAS No.1176760-49-8, Kinesin-like protein 1 inhibitor

Item Number

A607871

Grouped product items
SKU	Size	Availability	Price	Qty
A607871-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,000.90
A607871-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	AZD-4877 \| AZD4877 \| 1176760-49-8 \| AZD 4877 \| CHEMBL1829433 \| 19ORU63E06 \| 758722-49-5 \| N-(3-aminopropyl)-N-(1-(5-benzyl-3-methyl-4-oxo-4,5-dihydroisothiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl)-4-methylbenzamide \| n-(3-aminopropyl)-n-[1-(5-benzyl-3-methyl-4-oxo-4,5-
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Kinesin-like protein 1 inhibitor

Names and Identifiers

IUPAC Name	N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide
INCHI	InChI=1S/C28H33N5O2S/c1-18(2)24(32(16-8-15-29)27(34)22-13-11-19(3)12-14-22)25-30-26-23(20(4)31-36-26)28(35)33(25)17-21-9-6-5-7-10-21/h5-7,9-14,18,24H,8,15-17,29H2,1-4H3
InChi Key	SMFXSYMLJDHGIE-UHFFFAOYSA-N
Canonical SMILES	CC1=CC=C(C=C1)C(=O)N(CCCN)C(C2=NC3=C(C(=NS3)C)C(=O)N2CC4=CC=CC=C4)C(C)C
Isomeric SMILES	CC1=CC=C(C=C1)C(=O)N(CCCN)C(C2=NC3=C(C(=NS3)C)C(=O)N2CC4=CC=CC=C4)C(C)C
Alternate CAS	1176760-49-8
PubChem CID	10368812
MeSH Entry Terms	AZD 4877;AZD-4877;AZD4877;N-(3-aminopropyl)-N-(1-(5-benzyl-3-methyl-4-oxo-(1,2)thiazolo(5,4-d)pyrimidin-6-yl)-2-methylpropyl)-4-methylbenzamide

References

1. Theoclitou ME, Aquila B, Block MH, Brassil PJ, Castriotta L, Code E, Collins MP, Davies AM, Deegan T, Ezhuthachan J et al.. (2011) Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.. J Med Chem, 54 (19): (6734-50). [PMID:21899292] [10.1021/op500134e]

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Basic Description