AZD4547 - ≥99%, high purity , CAS No.1035270-39-3, Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fibroblast growth factor receptor 2;Inhibitor of fibroblast growth factor receptor 3;Inhibitor of fibroblast growth factor receptor 4;Inhibitor of Insulin-like growth factor I receptor;Inhibito
AZD4547 - ≥99%, high purity , CAS No.1035270-39-3, Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fibroblast growth factor receptor 2;Inhibitor of fibroblast growth factor receptor 3;Inhibitor of fibroblast growth factor receptor 4;Inhibitor of Insulin-like growth factor I receptor;Inhibito
AZD4547 is a novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3. AZD4547 treatment potently inhibits FGFR and MAPK phosphorylation in tumor cell lines in a dose-dependent manner.Novel, selective\xa0inhibitor\xa0of the FGFR1, 2, and 3 tyrosin
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fibroblast growth factor receptor 2;Inhibitor of fibroblast growth factor receptor 3;Inhibitor of fibroblast growth factor receptor 4;Inhibitor of Insulin-like growth factor I receptor;Inhibito
Product Description
AZD4547 is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3. A novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3.
1.Yanran Bi, Ruiling Zheng, Jiahao Hu, Ruiqing Shi, Junfeng Shi, Yutao Wang, Peng Wang, Wenyi Jiang, Gyudong Kim, Zhiguo Liu, Xiaokun Li, Li Lin. (2023) A novel FGFR1 inhibitor CYY292 suppresses tumor progression, invasion, and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis. Genes & Diseases, [PMID:37588207][10.1016/j.gendis.2023.02.035]
References
1.O'Brien A et al.. (2022) FGF1 Signaling Modulates Biliary Injury and Liver Fibrosis in the Mdr2-/- Mouse Model of Primary Sclerosing Cholangitis.. Hepatol Commun, 6 (7):(1574-1588). [PMID:35271760]
2.Akazawa Y et al.. (2015) Recruitment of mesenchymal stem cells by stromal cell-derived factor 1a in pulp cells from deciduous teeth.. Int J Mol Med, 36 (2):(442-8). [PMID:26082290]
3.Yanran Bi, Ruiling Zheng, Jiahao Hu, Ruiqing Shi, Junfeng Shi, Yutao Wang, Peng Wang, Wenyi Jiang, Gyudong Kim, Zhiguo Liu, Xiaokun Li, Li Lin. (2023) A novel FGFR1 inhibitor CYY292 suppresses tumor progression, invasion, and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis. Genes & Diseases, [PMID:37588207][10.1016/j.gendis.2023.02.035]
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