AZD4017 , 11-beta-hydroxysteroid dehydrogenase 1 inhibitor, CAS No.1024033-43-9, 11-beta-hydroxysteroid dehydrogenase 1 inhibitor

Item Number

A607866

Grouped product items
SKU	Size	Availability	Price	Qty
A607866-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
A607866-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

Basic Description

Synonyms	C22H33N3O3S \| SMR000466320 \| 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid \| CS-0007200 \| 3-PIPERIDINEACETIC ACID, 1-(5-((CYCLOHEXYLAMINO)CARBONYL)-6-(PROPYLTHIO)-2-PYRIDINYL)-, (3S)- \| Propyphenazone,(S) \| HY-
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	11-beta-hydroxysteroid dehydrogenase 1 inhibitor

Names and Identifiers

IUPAC Name	2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic acid
INCHI	InChI=1S/C22H33N3O3S/c1-2-13-29-22-18(21(28)23-17-8-4-3-5-9-17)10-11-19(24-22)25-12-6-7-16(15-25)14-20(26)27/h10-11,16-17H,2-9,12-15H2,1H3,(H,23,28)(H,26,27)/t16-/m0/s1
InChi Key	NCDZABJPWMBMIQ-INIZCTEOSA-N
Canonical SMILES	CCCSC1=C(C=CC(=N1)N2CCCC(C2)CC(=O)O)C(=O)NC3CCCCC3
Isomeric SMILES	CCCSC1=C(C=CC(=N1)N2CCC[C@H](C2)CC(=O)O)C(=O)NC3CCCCC3
PubChem CID	24946280
Molecular Weight	419.6

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.

References

1. Stimson RH, Walker BR. (2007) Glucocorticoids and 11beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome.. Minerva Endocrinol, 32 (3): (141-59). [PMID:17912154] [10.1021/op500134e]
2. Walker BR. (2007) Glucocorticoids and cardiovascular disease.. Eur J Endocrinol, 157 (5): (545-59). [PMID:17984234] [10.1021/op500134e]
3. Eckel RH, Grundy SM, Zimmet PZ. (2005) The metabolic syndrome.. Lancet, 365 (9468): (1415-28). [PMID:15836891] [10.1021/op500134e]
4. Scott JS, Bowker SS, Deschoolmeester J, Gerhardt S, Hargreaves D, Kilgour E, Lloyd A, Mayers RM, McCoull W, Newcombe NJ et al.. (2012) Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017).. J Med Chem, 55 (12): (5951-64). [PMID:22691057] [10.1021/op500134e]

Solution Calculators

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

Basic Description