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Home Bioactive Small Molecules AZD-9291 mesylate - 10mM in DMSO, high purity , CAS No.1421373-66-1, Epidermal growth factor receptor erbB1 inhibitor
AZD-9291 mesylate - 10mM in DMSO, high purity , CAS No.1421373-66-1, Epidermal growth factor receptor erbB1 inhibitor
Osimertinib mesylate (AZD9291) is the mesylate form of osimertinib, which is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug.
Basic Description Synonyms N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate | OSIMERTINIB MESYLATE [ORANGE BOOK] | S5078 | N-(2-((2-(dimethylamino)ethyl)methylamino)-4-methoxy-5-((4-(1-met Specifications & Purity 10mM in DMSO Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Action Type INHIBITOR Mechanism of action Epidermal growth factor receptor erbB1 inhibitor
Names and Identifiers IUPAC Name N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide;methanesulfonic acid INCHI InChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4) InChi Key FUKSNUHSJBTCFJ-UHFFFAOYSA-N Canonical SMILES CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC.CS(=O)(=O)O Isomeric SMILES CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC.CS(=O)(=O)O Alternate CAS 1421373-66-1,2070014-82-1 PubChem CID 78357807 MeSH Entry Terms AZD-9291;AZD-9291 mesylate;AZD9291;AZD9291 mesylate;mereletinib;mereletinib mesilate;mereletinib mesylate;N-(2-((2-(dimethylamino)ethyl)methylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)phenyl)-2-propenamide;N-(2-((2-(dimethylamino Molecular Weight 595.71
Certificates（CoA,COO,BSE/TSE and Analysis Chart) Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS09 , GHS07 Signal Danger Hazard Statements H302: Harmful if swallowed
H317: May cause an allergic skin reaction
H400: Very toxic to aquatic life
H410: Very toxic to aquatic life with long lasting effects
H372: Causes damage to organs through prolonged or repeated exposure
H360: May damage fertility or the unborn child
H361: Suspected of damaging fertility or the unborn child
H362: May cause harm to breast-fed children
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P272: Contaminated work clothing should not be allowed out of the workplace.
P333+P313: IF SKIN irritation or rash occurs: Get medical advice/attention.
P362+P364: Take off contaminated clothing and wash it before reuse.
P391: Collect spillage.
P330: Rinse mouth.
P263: Avoid contact during pregnancy/while nursing.
P203: Obtain, read and follow all safety instructions before use.
P301+P317: IF SWALLOWED: Get medical help.
P318: if exposed or concerned, get medical advice.
P319: Get medical help if you feel unwell.
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