Arvanil - ≥98%(HPLC), high purity , CAS No.128007-31-8, Activator of TRPV1

Item Number

A288783

Grouped product items
SKU	Size	Availability	Price	Qty
A288783-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$177.90
A288783-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$286.90

Potent CB1agonist; also anandamide transport inhibitor and TRPV1 agonist

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Basic Description

Synonyms	NCGC00184560-03 \| CHEBI:187796 \| NAVA \| N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide \| Q27074515 \| AKOS024456544 \| BSPBio_001388 \| HMS1361F10 \| NCGC00162411-03 \| N-arachidonoyl vanillylamine \| HMS1989F10 \| BCBcMAP01_000243 \| N-Va
Specifications & Purity	Moligand™, ≥98%, 50mg/ml in ethanol
Biochemical and Physiological Mechanisms	Cannabinoid CB1and vanilloid TRPV1 (VR1) agonist (Kivalues are 0.5 and 0.3μM respectively). Also inhibits the anandamide transporter (IC50= 3.6μM). Analgesic, vasodilatory and anti-inflammatoryin vivo.
Storage Temp	Protected from light,Store at -20°C,Argon charged,Desiccated
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of TRPV1
Product Description	Arvanil (N-Vanillylarachidonamide) is a synthetic capsaicin-amphetamine hybrid and a ligand for vanilloid receptor 1 (VR1) and cannabinoid receptor 1 (CB1), exhibiting neuroprotective activity, inhibiting spasm, and enhancing cisplatin chemotherapy sensitivity by inducing ferroptosis in HCC cells in vivo. It induces ferroptosis in liver cancer cells via binding to MICU1.

Names and Identifiers

IUPAC Name	(5Z,8Z,11Z,14Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]icosa-5,8,11,14-tetraenamide
INCHI	InChI=1S/C28H41NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-28(31)29-24-25-21-22-26(30)27(23-25)32-2/h7-8,10-11,13-14,16-17,21-23,30H,3-6,9,12,15,18-20,24H2,1-2H3,(H,29,31)/b8-7-,11-10-,14-13-,17-16-
InChi Key	QVLMCRFQGHWOPM-ZKWNWVNESA-N
Canonical SMILES	CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCC1=CC(=C(C=C1)O)OC
Isomeric SMILES	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC1=CC(=C(C=C1)O)OC
Molecular Weight	439.64

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Basic Description