| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| A288690-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $318.90 |
High affinity, selective NPR3 antagonist
| Product Name | AP 811, Antagonist of natriuretic peptide receptor 3, CAS No.124833-45-0 |
|---|---|
| Grade | Moligand™ |
| Product Description |
AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation.
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| Specifications & Purity | Moligand™, ≥98% |
| Biochemical and Physiological Mechanisms | High affinity, selective ANP clearance receptor (NPR3) antagonist (Ki= 0.45 nM). Exhibits >20,000-fold selectivity for NPR3 over NPR1. Inhibits ANP-stimulated Na+/K+pump activity in rabbit ventricular cardiomyocytesin vitro. Also blocks proliferation of r |
| Sequence | RIDR(Modifications: Arg-1 = N2-[4-(2-Naphthoylamino)phenylacetyl], Arg-4 = C-terminal (S)-2-methylbutylamide) |
| Action Type | ANTAGONIST |
| Mechanism of action | Antagonist of natriuretic peptide receptor 3 |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| Storage Temp | Store at -20°C |
|---|---|
| Shipped In | Ice chest + Ice pads |
| CAS | 124833-45-0 |
