Grouped product items

SKU

Size

Availability

Price

Qty

A123260-1g

$90.90

A123260-5g

$286.90

A123260-10g

10g

Available within 4-8 weeks(?)

$516.90

A123260-25g

25g

$1,162.90

A123260-100g

100g

$4,184.90

Basic Description

Synonyms	88150-42-9 (free base) \| 3-Ethyl-5-methyl (+-)-2-((2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate \| AMLODIPINE (MART.) \| BDBM50088383 \| NCGC00165957-02 \| Norvasc (TN) \| 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-3-e
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Potent, long-acting L-type calcium channel blocker (IC 50 =1.9 nM). Also stimulates nitric oxide synthase (NOS), lowers blood pressure and has antioxidant properties.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR, GATING INHIBITOR
Mechanism of action	Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Allosteric modulator of P2X4
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer.

AI Insight

Names and Identifiers

Pubchem Sid	488179669
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179669
IUPAC Name	3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
INCHI	InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
InChi Key	HTIQEAQVCYTUBX-UHFFFAOYSA-N
Canonical SMILES	CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
Isomeric SMILES	CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
PubChem CID	2162
Molecular Weight	408.88

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot Number	Certificate Type	Date	Item
I2318165	Certificate of Analysis	Sep 25, 2023	A123260
H2309517	Certificate of Analysis	Aug 17, 2023	A123260
J1921140	Certificate of Analysis	Aug 04, 2023	A123260
C2302442	Certificate of Analysis	Mar 15, 2023	A123260
C2302447	Certificate of Analysis	Mar 06, 2023	A123260
C2302443	Certificate of Analysis	Mar 06, 2023	A123260
B2428140	Certificate of Analysis	Jul 21, 2022	A123260
H2217132	Certificate of Analysis	Jul 21, 2022	A123260
H2217133	Certificate of Analysis	Jul 21, 2022	A123260
H2217134	Certificate of Analysis	Jul 21, 2022	A123260
J2421296	Certificate of Analysis	Jul 21, 2022	A123260

Show more⌵

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS09, GHS05
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H373:Causes damage to organs through prolonged or repeated exposure H318:Causes serious eye damage H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P319:Get medical help if you feel unwell.

Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Chehao Lee, Guang Xin, Fan Li, Chengyu Wan, Xiuxian Yu, Lijuan Feng, Ao Wen, Yu Cao, Wen Huang. (2023) Calcium/P53/Ninjurin 1 Signaling Mediates Plasma Membrane Rupture of Acinar Cells in Severe Acute Pancreatitis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (14): (11554). [PMID:37511311] [10.3390/ijms241411554]
2. Ruike Song, Yanxia Li, Yiting Chen, Zhenli Qiu, Lu Huang. (2023) Chiral covalent organic framework incorporated organic polymer monolithic capillary column for enantioseparations. JOURNAL OF SEPARATION SCIENCE, 46 (8): (2201039). [PMID:36750206] [10.1002/jssc.202201039]
3. Zhimin Gong, Gaobo Wang, Shuai Shao, Mengjie Wang, Kun Lu, Shixiang Gao. (2022) Co-degradation of coexisting pollutants methylparaben (mediators) and amlodipine in enzyme-mediator systems: Insight into the mediating mechanism. JOURNAL OF HAZARDOUS MATERIALS, 423 (127112). [PMID:34523479] [10.1016/j.jhazmat.2021.127112]
4. Zhu-Jun Zhong, Zhong-Ping Yao, Zi-Qi Shi, Yang-Dan Liu, Li-Fang Liu, Gui-Zhong Xin. (2021) Measurement of Intracellular Nitric Oxide with a Quantitative Mass Spectrometry Probe Approach. ANALYTICAL CHEMISTRY, 93 (24): (8536–8543). [PMID:34107211] [10.1021/acs.analchem.1c01259]
5. Yujie Zhang, Hui Zhong, Shouyong Zhou, Haifeng Han, Mingliang Zhang, Hongdeng Qiu. (2021) A docosyl-terminated polyamine amphiphile-bonded stationary phase for multimodal separations in liquid chromatography. JOURNAL OF CHROMATOGRAPHY A, 1642 (462045). [PMID:33735643] [10.1016/j.chroma.2021.462045]
6. Lelin Zeng, Qin Yi, Qian Liu, Kewen Tang, Bart Van der Bruggen. (2021) Development of a new method and device for chiral drug enrichment and enantioseparation: Multiple-phase extraction and in situ coupling of crystallization. SEPARATION AND PURIFICATION TECHNOLOGY, 257 (117884). [PMID:] [10.1016/j.seppur.2020.117884]
7. Lelin Zeng, Qian Liu, Bart Van der Bruggen, Kewen Tang, Xiang Yi, Guoxiang Wang. (2020) An integrated separation process for recovery and enantioseparation of amlodipine from wastewater: Supported liquid membrane-aqueous/organic phase crystallization. SEPARATION AND PURIFICATION TECHNOLOGY, 248 (117121). [PMID:] [10.1016/j.seppur.2020.117121]
8. Shuai Shao, Li Qian, Xin Zhan, Mengjie Wang, Kun Lu, Jianbiao Peng, Dong Miao, Shixiang Gao. (2020) Transformation and toxicity evolution of amlodipine mediated by cobalt ferrite activated peroxymonosulfate: Effect of oxidant concentration. CHEMICAL ENGINEERING JOURNAL, 382 (123005). [PMID:] [10.1016/j.cej.2019.123005]

References

1. Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP et al.. (2014) International union of basic and clinical pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.. Pharmacol Rev, 66 (4): (918-47). [PMID:25026896] [10.1021/op500134e]
2. Chehao Lee, Guang Xin, Fan Li, Chengyu Wan, Xiuxian Yu, Lijuan Feng, Ao Wen, Yu Cao, Wen Huang. (2023) Calcium/P53/Ninjurin 1 Signaling Mediates Plasma Membrane Rupture of Acinar Cells in Severe Acute Pancreatitis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (14): (11554). [PMID:37511311] [10.3390/ijms241411554]
3. Ruike Song, Yanxia Li, Yiting Chen, Zhenli Qiu, Lu Huang. (2023) Chiral covalent organic framework incorporated organic polymer monolithic capillary column for enantioseparations. JOURNAL OF SEPARATION SCIENCE, 46 (8): (2201039). [PMID:36750206] [10.1002/jssc.202201039]
4. Zhimin Gong, Gaobo Wang, Shuai Shao, Mengjie Wang, Kun Lu, Shixiang Gao. (2022) Co-degradation of coexisting pollutants methylparaben (mediators) and amlodipine in enzyme-mediator systems: Insight into the mediating mechanism. JOURNAL OF HAZARDOUS MATERIALS, 423 (127112). [PMID:34523479] [10.1016/j.jhazmat.2021.127112]
5. Zhu-Jun Zhong, Zhong-Ping Yao, Zi-Qi Shi, Yang-Dan Liu, Li-Fang Liu, Gui-Zhong Xin. (2021) Measurement of Intracellular Nitric Oxide with a Quantitative Mass Spectrometry Probe Approach. ANALYTICAL CHEMISTRY, 93 (24): (8536–8543). [PMID:34107211] [10.1021/acs.analchem.1c01259]
6. Yujie Zhang, Hui Zhong, Shouyong Zhou, Haifeng Han, Mingliang Zhang, Hongdeng Qiu. (2021) A docosyl-terminated polyamine amphiphile-bonded stationary phase for multimodal separations in liquid chromatography. JOURNAL OF CHROMATOGRAPHY A, 1642 (462045). [PMID:33735643] [10.1016/j.chroma.2021.462045]
7. Lelin Zeng, Qin Yi, Qian Liu, Kewen Tang, Bart Van der Bruggen. (2021) Development of a new method and device for chiral drug enrichment and enantioseparation: Multiple-phase extraction and in situ coupling of crystallization. SEPARATION AND PURIFICATION TECHNOLOGY, 257 (117884). [PMID:] [10.1016/j.seppur.2020.117884]
8. Lelin Zeng, Qian Liu, Bart Van der Bruggen, Kewen Tang, Xiang Yi, Guoxiang Wang. (2020) An integrated separation process for recovery and enantioseparation of amlodipine from wastewater: Supported liquid membrane-aqueous/organic phase crystallization. SEPARATION AND PURIFICATION TECHNOLOGY, 248 (117121). [PMID:] [10.1016/j.seppur.2020.117121]
9. Shuai Shao, Li Qian, Xin Zhan, Mengjie Wang, Kun Lu, Jianbiao Peng, Dong Miao, Shixiang Gao. (2020) Transformation and toxicity evolution of amlodipine mediated by cobalt ferrite activated peroxymonosulfate: Effect of oxidant concentration. CHEMICAL ENGINEERING JOURNAL, 382 (123005). [PMID:] [10.1016/j.cej.2019.123005]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Amlodipine - 98%, high purity , CAS No.88150-42-9, Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Allosteric modulator of P2X4