Basic Description

Synonyms	amitriptyline \| 50-48-6 \| Damitriptyline \| Amitriptylin \| Triptanol \| Flavyl \| Seroten \| Proheptadiene \| Elavil \| Lantron \| Triptisol \| Tryptanol \| Adepress \| Adepril \| Damilen \| Amitryptiline \| Triptilin \| Redomex \| Amitriprolidine \| Laroxyl \| Amytriptylin \| Amitriptilina \| Amitriptylinum \| Amitrypt
Specifications & Purity	Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms	Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST, CHANNEL BLOCKER, INHIBITOR
Mechanism of action	Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2C receptor;Antagonist of 5-HT 6 receptor;Antagonist of 5-HT 7 receptor;Antagonist of H 1 receptor;Channel blocker of K ir3.2;Channel blocker of K ir3.4;Antagonist of LPA 1 receptor;Antagonist of M 1 recep
Product Description	Information Amitriptyline Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1 , histamine receptor H4 , 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid.

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine
INCHI	InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
InChi Key	KRMDCWKBEZIMAB-UHFFFAOYSA-N
Canonical SMILES	CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
Isomeric SMILES	CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
PubChem CID	2160
Molecular Weight	277.41

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS09, GHS05, GHS07
Signal	Danger
Hazard Statements	H302:Harmful if swallowed H318:Causes serious eye damage H410:Very toxic to aquatic life with long lasting effects H361:Suspected of damaging fertility or the unborn child H301+H311+H331:Toxic if swallowed, in contact with skin or if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P391:Collect spillage. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P316:Get emergency medical help immediately.

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Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yujie Cao, Tianran Sheng, Jinfei Mei, Peng Qian, Deqian Huang, Liangquan Sheng, Guoping Sheng. (2022) Abundant oxygen vacancies constructed by deep reduction strategy to achieve ultra-high peroxomonosulfate activation efficiency for degrading organic pollutions in water. APPLIED CATALYSIS B-ENVIRONMENTAL, 319 (121892). [PMID:] [10.1016/j.apcatb.2022.121892]
2. Zhihong Yao, Shishi Li, Zifei Qin, Xiaodan Hong, Yi Dai, Baojian Wu, Wencai Ye, Frank J. Gonzalez, Xinsheng Yao. (2017) Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol in Psoralea corylifolia L.. RSC Advances, 7 (83): (52661-52671). [PMID:] [10.1039/C7RA10376J]
3. Pengchao Xie, Yizhou Guo, Yiqun Chen, Zongping Wang, Ran Shang, Songlin Wang, Jiaqi Ding, Ying Wan, Wei Jiang, Jun Ma. (2017) Application of a novel advanced oxidation process using sulfite and zero-valent iron in treatment of organic pollutants. CHEMICAL ENGINEERING JOURNAL, 314 (240). [PMID:] [10.1016/j.cej.2016.12.094]

References

1. Yujie Cao, Tianran Sheng, Jinfei Mei, Peng Qian, Deqian Huang, Liangquan Sheng, Guoping Sheng. (2022) Abundant oxygen vacancies constructed by deep reduction strategy to achieve ultra-high peroxomonosulfate activation efficiency for degrading organic pollutions in water. APPLIED CATALYSIS B-ENVIRONMENTAL, 319 (121892). [PMID:] [10.1016/j.apcatb.2022.121892]
2. Zhihong Yao, Shishi Li, Zifei Qin, Xiaodan Hong, Yi Dai, Baojian Wu, Wencai Ye, Frank J. Gonzalez, Xinsheng Yao. (2017) Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol in Psoralea corylifolia L.. RSC Advances, 7 (83): (52661-52671). [PMID:] [10.1039/C7RA10376J]
3. Pengchao Xie, Yizhou Guo, Yiqun Chen, Zongping Wang, Ran Shang, Songlin Wang, Jiaqi Ding, Ying Wan, Wei Jiang, Jun Ma. (2017) Application of a novel advanced oxidation process using sulfite and zero-valent iron in treatment of organic pollutants. CHEMICAL ENGINEERING JOURNAL, 314 (240). [PMID:] [10.1016/j.cej.2016.12.094]

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Basic Description

AI Insight

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Safety and Hazards(GHS)

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Reviews

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Citations of This Product

References

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