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Acitretin - 98%, high purity , Retinoid receptor agonist, CAS No.55079-83-9, Retinoid receptor agonist
Synthetic, highly lipophilic retinoid
Basic Description Synonyms Acitretin | ACITRETIN [HSDB] | (2E,4E,6E,8E)-3,7-dimethyl-9-[2,3,6-trimethyl-4-(methyloxy)phenyl]nona-2,4,6,8-tetraenoic acid | AKOS015889991 | Q341500 | Ro-10-1670 | SMR000499573 | 9-cis Acitretin | Soriatane | Neotigason | Acitretin- Bio-X | Z2312273468 Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Synthetic retinoid that is a metabolite of etretinate. Preferentially binds to cellular retinoic acid binding proteins (CRABPs).Synthetic, highly lipophilic retinoid. Etretinate metabolite with a shorter half-life. Increases ADAM10 gene expression. Induce Storage Temp Protected from light,Store at -20°C,Argon charged Shipped In Ice chest + Ice pads Grade Moligand™ Action Type AGONIST Mechanism of action Retinoid receptor agonist Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description It is a potent activator of the α-secretase ADAM10 gene expression and apoptosis inducer via the CD95 signalling pathway. It is also a systemic retinoid drug used in the treatment of severe psoriasis.
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers Pubchem Sid 488195292 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488195292 IUPAC Name (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid INCHI InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+ InChi Key IHUNBGSDBOWDMA-AQFIFDHZSA-N Canonical SMILES CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC Isomeric SMILES CC1=CC(=C(C(=C1/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C)C)C)OC WGK Germany 3 PubChem CID 5284513 UN Number 3077 Molecular Weight 326.43
Certificates（CoA,COO,BSE/TSE and Analysis Chart) Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS09 , GHS07 Signal Danger Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H400: Very toxic to aquatic life
H410: Very toxic to aquatic life with long lasting effects
H360: May damage fertility or the unborn child
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P362+P364: Take off contaminated clothing and wash it before reuse.
P391: Collect spillage.
P203: Obtain, read and follow all safety instructions before use.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P318: if exposed or concerned, get medical advice.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
WGK Germany 3 Merck Index 112
Citations of This Product 1. Yongjie Bao, Wenni Rong, An Zhu, Yuan Chen, Huiyue Chen, Yirui Hong, Jingyang Le, Qiyao Wang, C. Benjamin Naman, Zhipeng Xu, Lin Liu, Wei Cui, Xiang Wu. (2023) Retinoic Acid Receptor Is a Novel Therapeutic Target for Postoperative Cognitive Dysfunction. Pharmaceutics, 15 (9): (2311). [PMID:37765280 ] [10.3390/pharmaceutics15092311 ]
References 1. Yongjie Bao, Wenni Rong, An Zhu, Yuan Chen, Huiyue Chen, Yirui Hong, Jingyang Le, Qiyao Wang, C. Benjamin Naman, Zhipeng Xu, Lin Liu, Wei Cui, Xiang Wu. (2023) Retinoic Acid Receptor Is a Novel Therapeutic Target for Postoperative Cognitive Dysfunction. Pharmaceutics, 15 (9): (2311). [PMID:37765280 ] [10.3390/pharmaceutics15092311 ]
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