A 286982 - 98%, high purity , CAS No.280749-17-9, Inhibitor of integrin αLβ2

Item Number

A288284

Grouped product items
SKU	Size	Availability	Price
A288284-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$83.90
A288284-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$132.90
A288284-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$266.90
A288284-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$444.90
A288284-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$801.90

Potent inhibitor of the LFA-1/ICAM-1 interaction

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Basic Description

Synonyms	A286982 \| A899560 \| UNII-5I8WFS075A \| BDBM50092956 \| F77491 \| A 286,982 \| (2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one \| A286982 \| A-286982 \| cid_108661 \| GTPL6592 \| A 286982 \| 1-(4-Acetyl-piperazin-1-
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Potent inhibitor of the LFA-1/ICAM-1 interaction (IC50values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively).Lymphocyte function-associated antigen-1 (LFA-1) is a member of the leukocyte integrin family, whic
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of integrin αLβ2

Names and Identifiers

IUPAC Name	(E)-1-(4-acetylpiperazin-1-yl)-3-[3-nitro-4-(2-propan-2-ylphenyl)sulfanylphenyl]prop-2-en-1-one
INCHI	InChI=1S/C24H27N3O4S/c1-17(2)20-6-4-5-7-22(20)32-23-10-8-19(16-21(23)27(30)31)9-11-24(29)26-14-12-25(13-15-26)18(3)28/h4-11,16-17H,12-15H2,1-3H3/b11-9+
InChi Key	HTGGAYLWTDOFDK-PKNBQFBNSA-N
Canonical SMILES	CC(C)C1=CC=CC=C1SC2=C(C=C(C=C2)C=CC(=O)N3CCN(CC3)C(=O)C)[N+](=O)[O-]
Isomeric SMILES	CC(C)C1=CC=CC=C1SC2=C(C=C(C=C2)/C=C/C(=O)N3CCN(CC3)C(=O)C)[N+](=O)[O-]
PubChem CID	9846729
Molecular Weight	453.55

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5 results found

Lot Number	Certificate Type	Date	Item
J2112126	Certificate of Analysis	Jul 19, 2024	A288284
J2112127	Certificate of Analysis	Jul 19, 2024	A288284
J2112128	Certificate of Analysis	Jul 19, 2024	A288284
J2112129	Certificate of Analysis	Jul 19, 2024	A288284
J2112130	Certificate of Analysis	Jul 19, 2024	A288284

References

1. Liu G, Link JT, Pei Z, Reilly EB, Leitza S, Nguyen B, Marsh KC, Okasinski GF, von Geldern TW, Ormes M et al.. (2000) Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead.. J Med Chem, 43 (21): (4025-40). [PMID:11052808] [10.1021/op500134e]

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Basic Description